Repurposing Ferumoxytol as a Breast Cancer-Associated Macrophage Tracer with Five-Dimensional Quantitative [Fe]MRI of SPION Dynamics

Repurposing Ferumoxytol as a Breast Cancer-Associated Macrophage Tracer with Five-Dimensional Quantitative [Fe]MRI of SPION Dynamics

Tumor-associated macrophages (TAMs) in breast cancer regulate inflammation, immunosuppression, angiogenesis, and metastasis. However, TAM imaging remains a clinical challenge. Ferumoxytol has long been an FDA-approved superparamagnetic iron oxide nanoparticle (SPION) preparation used as an intraveno...

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Bibliographic Details
Main Authors: Laurel O. Sillerud, Alexander J. Neuwelt, Fernanda I. Staquicini, Wadih Arap, Renata Pasqualini
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
ferumoxytol
triple-negative breast cancer
MRI
[Fe]MRI
Online Access:https://www.mdpi.com/2072-6694/13/15/3802

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