Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections?
INTRODUCTION[|]This study was an evaluation of differences in the inflammatory markers of C-reactive protein (CRP) level, the neutrophil-to-lymphocyte ratio (NLR), the platelet count-to-mean platelet volume ratio (PLT/MPV), and the platelet-to-lymphocyte ratio (PLR) in patients with pulmonary candid...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2018-09-01
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| Series: | Southern Clinics of Istanbul Eurasia |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-92486 |
| _version_ | 1797922506661691392 |
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| author | Armağan Fatma Hazar Hatice Türker |
| author_facet | Armağan Fatma Hazar Hatice Türker |
| author_sort | Armağan Fatma Hazar |
| collection | DOAJ |
| description | INTRODUCTION[|]This study was an evaluation of differences in the inflammatory markers of C-reactive protein (CRP) level, the neutrophil-to-lymphocyte ratio (NLR), the platelet count-to-mean platelet volume ratio (PLT/MPV), and the platelet-to-lymphocyte ratio (PLR) in patients with pulmonary candidiasis and pulmonary aspergillosis.[¤]METHODS[|]A retrospective, cross-sectional study was performed with the data of patients who were diagnosed with pulmonary candidiasis and pulmonary aspergillosis between 2016 and 2017 according to the records of the hospital information system. The results and date of hemograms, the biochemistry values, and C-reactive protein (CRP) levels were recorded. The NLR, PLT/MPV, and PLR were calculated. The documented parameters of the study groups were compared and analyzed.[¤]RESULTS[|]There were 44 patients (29 men) (candidiasis, n=19; aspergillosis, n=25), with a median age of 65 years. In both groups, the incidence of chronic obstructive pulmonary disease, level of CRP, and the NLR, PLR, MPV, and PLT/MPV were statistically similar. At discharge, the CRP, PLR, NLR, and PLT values were still similar in the 2 groups; however, the MPV was significantly lower in the pulmonary aspergillosis group when compared with the pulmonary candidiasis group (7.3 vs 8.4; p=0029).[¤]DISCUSSION AND CONCLUSION[|]Most biomarkers were similar in the pulmonary aspergillosis and the candidiasis groups; however, a PLT elevation and an MPV decrease were significant in the diagnosis of aspergillus. Similar findings in prospective, multicenter studies performed with patients who are suspected of having a fungal lung infection will add to the ultimate determination of the value to be given to PLT and MPV biomarkers in the initiation of empirical treatment.[¤] |
| first_indexed | 2024-04-10T14:32:30Z |
| format | Article |
| id | doaj.art-29c22925527b4fb08436996bc94e1f51 |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T14:32:30Z |
| publishDate | 2018-09-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-29c22925527b4fb08436996bc94e1f512023-02-15T16:08:42ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982018-09-0129316817510.14744/scie.2018.92486SCIE-92486Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections?Armağan Fatma Hazar0Hatice Türker1Department of Chest Diseases, University of Health Sciences İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyINTRODUCTION[|]This study was an evaluation of differences in the inflammatory markers of C-reactive protein (CRP) level, the neutrophil-to-lymphocyte ratio (NLR), the platelet count-to-mean platelet volume ratio (PLT/MPV), and the platelet-to-lymphocyte ratio (PLR) in patients with pulmonary candidiasis and pulmonary aspergillosis.[¤]METHODS[|]A retrospective, cross-sectional study was performed with the data of patients who were diagnosed with pulmonary candidiasis and pulmonary aspergillosis between 2016 and 2017 according to the records of the hospital information system. The results and date of hemograms, the biochemistry values, and C-reactive protein (CRP) levels were recorded. The NLR, PLT/MPV, and PLR were calculated. The documented parameters of the study groups were compared and analyzed.[¤]RESULTS[|]There were 44 patients (29 men) (candidiasis, n=19; aspergillosis, n=25), with a median age of 65 years. In both groups, the incidence of chronic obstructive pulmonary disease, level of CRP, and the NLR, PLR, MPV, and PLT/MPV were statistically similar. At discharge, the CRP, PLR, NLR, and PLT values were still similar in the 2 groups; however, the MPV was significantly lower in the pulmonary aspergillosis group when compared with the pulmonary candidiasis group (7.3 vs 8.4; p=0029).[¤]DISCUSSION AND CONCLUSION[|]Most biomarkers were similar in the pulmonary aspergillosis and the candidiasis groups; however, a PLT elevation and an MPV decrease were significant in the diagnosis of aspergillus. Similar findings in prospective, multicenter studies performed with patients who are suspected of having a fungal lung infection will add to the ultimate determination of the value to be given to PLT and MPV biomarkers in the initiation of empirical treatment.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-92486aspergillosiscandidiasismean platelet volume; neutrophil-to-lymphocyte ratio; platelet count/mean platelet volume; pulmonary fungal infection. |
| spellingShingle | Armağan Fatma Hazar Hatice Türker Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? Southern Clinics of Istanbul Eurasia aspergillosis candidiasis mean platelet volume; neutrophil-to-lymphocyte ratio; platelet count/mean platelet volume; pulmonary fungal infection. |
| title | Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? |
| title_full | Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? |
| title_fullStr | Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? |
| title_full_unstemmed | Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? |
| title_short | Which Biomarkers Help to Distinguish Between Candida and Aspergillus in Patients with Pulmonary Infections? |
| title_sort | which biomarkers help to distinguish between candida and aspergillus in patients with pulmonary infections |
| topic | aspergillosis candidiasis mean platelet volume; neutrophil-to-lymphocyte ratio; platelet count/mean platelet volume; pulmonary fungal infection. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-92486 |
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