Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern
Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consump...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/5/1038 |
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| author | Beatriz Rodrigues Risuenho Peinado Walessa Alana Bragança Aragão Cristian dos Santos Pereira Diane Cleydes Baia da Silva Railson de Oliveira Ferreira Antônio Hernandes Chaves-Neto Luanna Melo Pereira Fernandes Rafael Rodrigues Lima |
| author_facet | Beatriz Rodrigues Risuenho Peinado Walessa Alana Bragança Aragão Cristian dos Santos Pereira Diane Cleydes Baia da Silva Railson de Oliveira Ferreira Antônio Hernandes Chaves-Neto Luanna Melo Pereira Fernandes Rafael Rodrigues Lima |
| author_sort | Beatriz Rodrigues Risuenho Peinado |
| collection | DOAJ |
| description | Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. Thus, 32 male Wistar rats were divided into four groups: control (sedentary animals treated with water); training (trained animals treated with EtOH); EtOH (sedentary animals treated with EtOH); and EtOH + training (trained animals treated with ethanol). EtOH was administered to the animals at a dose of 3 g/kg/day at a concentration of 20% <i>w/v</i> for three consecutive days per week via intragastric gavage. The training was performed on a treadmill for five successive days. At the end of the 4-week experimental protocol, the animals were euthanized, and salivary glands and saliva were collected for oxidative biochemistry analysis. Our results showed that EtOH consumption generated changes in the oxidative biochemistry of the salivary glands and saliva. Thus, it was possible to conclude that moderate physical exercise can significantly recover antioxidant activity, reducing the damage generated by EtOH. |
| first_indexed | 2024-03-11T03:59:22Z |
| format | Article |
| id | doaj.art-29c2813ae00c424b9ce40e5d3ae825b1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T03:59:22Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-29c2813ae00c424b9ce40e5d3ae825b12023-11-18T00:14:35ZengMDPI AGAntioxidants2076-39212023-05-01125103810.3390/antiox12051038Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol PatternBeatriz Rodrigues Risuenho Peinado0Walessa Alana Bragança Aragão1Cristian dos Santos Pereira2Diane Cleydes Baia da Silva3Railson de Oliveira Ferreira4Antônio Hernandes Chaves-Neto5Luanna Melo Pereira Fernandes6Rafael Rodrigues Lima7Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilDepartment of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16066840, BrazilDepartment of Morphology and Physiological Sciences, Center of Sciences Biological and Health, State University of Pará, Belém 66087662, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, BrazilHeavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. Thus, 32 male Wistar rats were divided into four groups: control (sedentary animals treated with water); training (trained animals treated with EtOH); EtOH (sedentary animals treated with EtOH); and EtOH + training (trained animals treated with ethanol). EtOH was administered to the animals at a dose of 3 g/kg/day at a concentration of 20% <i>w/v</i> for three consecutive days per week via intragastric gavage. The training was performed on a treadmill for five successive days. At the end of the 4-week experimental protocol, the animals were euthanized, and salivary glands and saliva were collected for oxidative biochemistry analysis. Our results showed that EtOH consumption generated changes in the oxidative biochemistry of the salivary glands and saliva. Thus, it was possible to conclude that moderate physical exercise can significantly recover antioxidant activity, reducing the damage generated by EtOH.https://www.mdpi.com/2076-3921/12/5/1038alcoholbinge-drinkingsalivary glandmoderate physical trainingoxidative biochemistry |
| spellingShingle | Beatriz Rodrigues Risuenho Peinado Walessa Alana Bragança Aragão Cristian dos Santos Pereira Diane Cleydes Baia da Silva Railson de Oliveira Ferreira Antônio Hernandes Chaves-Neto Luanna Melo Pereira Fernandes Rafael Rodrigues Lima Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern Antioxidants alcohol binge-drinking salivary gland moderate physical training oxidative biochemistry |
| title | Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| title_full | Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| title_fullStr | Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| title_full_unstemmed | Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| title_short | Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern |
| title_sort | physical exercise mitigates salivary gland and saliva damages in rats exposed to binge like ethanol pattern |
| topic | alcohol binge-drinking salivary gland moderate physical training oxidative biochemistry |
| url | https://www.mdpi.com/2076-3921/12/5/1038 |
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