| Summary: | This prospective clinical study evaluated the experiences and preferences of both patients and clinicians when performing class I–V cavity preparation procedures using a 9300 nm CO<sub>2</sub> laser without anesthetic. A total of 233 procedures were performed on 103 patients. Following treatment, patients were asked to describe discomfort/pain levels and preferences for future treatment with either laser treatment or traditional therapy. Additionally, clinicians were asked to rate their experiences with the procedures in three technical domains: speed, ease-of-use, and precision. In total, 98% of patients preferred laser treatment to traditional therapy and 93% of all procedures performed were completed with no anesthesia. Younger patients and patients receiving multiple restorations reported significantly higher discomfort, though discomfort scores were very low overall (below 3 on a 10-point pain scale). While there were significant differences in clinician experiences, each clinician reported having generally high satisfaction using the laser with respect to speed, ease of use, and precision. In conclusion, the 9300 nm CO<sub>2</sub> laser provides clinicians a viable option for cavity preparations in dentistry as evidenced by high rates of anesthesia-free procedures with low reported discomfort, the fact that nearly all patients would opt for laser use on future cavity preparations, and generally positive experiences reported by clinicians.
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