Tumor budding in upper gastrointestinal carcinomas
The basis of personalized medicine in oncology is the prediction of an individual’s risk of relapse and death from disease. The presence of tumor budding (TB) at the tumor-host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00216/full |
| _version_ | 1819267837068312576 |
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| author | Viktor Hendrik Koelzer Rupert eLanger Inti eZlobec Alessandro eLugli |
| author_facet | Viktor Hendrik Koelzer Rupert eLanger Inti eZlobec Alessandro eLugli |
| author_sort | Viktor Hendrik Koelzer |
| collection | DOAJ |
| description | The basis of personalized medicine in oncology is the prediction of an individual’s risk of relapse and death from disease. The presence of tumor budding (TB) at the tumor-host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as the presence of dedifferentiated cells or small clusters of up to five cells at the tumor invasive front and can be observed in aggressive carcinomas of the esophagus, stomach, pancreas, ampulla, colon and rectum. Presence of TB reproducibly correlates with advanced tumor stage, frequent lymphovascular invasion, nodal and distant metastasis. The UICC has officially recognized TB as additional independent prognostic factor in cancers of the colon and rectum. Recent studies have also characterized TB as a promising prognostic indicator for clinical management of esophageal squamous cell carcinoma, adenocarcinoma of the gastro-esophageal junction and gastric adenocarcinoma. However, several important issues have to be addressed for application in daily diagnostic practice: 1) Validation of prognostic scoring systems for tumor budding in large, multi-center studies 2) Consensus on the optimal assessment method 3) Inter-observer reproducibility. This review provides a comprehensive analysis of TB in cancers of the upper gastrointestinal tract including critical appraisal of perspectives for further study. |
| first_indexed | 2024-12-23T21:23:30Z |
| format | Article |
| id | doaj.art-29c4ca889f994e2ea0cc765460348d96 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T21:23:30Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-29c4ca889f994e2ea0cc765460348d962022-12-21T17:30:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-08-01410.3389/fonc.2014.00216108677Tumor budding in upper gastrointestinal carcinomasViktor Hendrik Koelzer0Rupert eLanger1Inti eZlobec2Alessandro eLugli3Clinical Pathology Division and Translational Research Unit, Institute of Pathology, University of BernClinical Pathology Division and Translational Research Unit, Institute of Pathology, University of BernClinical Pathology Division and Translational Research Unit, Institute of Pathology, University of BernClinical Pathology Division and Translational Research Unit, Institute of Pathology, University of BernThe basis of personalized medicine in oncology is the prediction of an individual’s risk of relapse and death from disease. The presence of tumor budding (TB) at the tumor-host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as the presence of dedifferentiated cells or small clusters of up to five cells at the tumor invasive front and can be observed in aggressive carcinomas of the esophagus, stomach, pancreas, ampulla, colon and rectum. Presence of TB reproducibly correlates with advanced tumor stage, frequent lymphovascular invasion, nodal and distant metastasis. The UICC has officially recognized TB as additional independent prognostic factor in cancers of the colon and rectum. Recent studies have also characterized TB as a promising prognostic indicator for clinical management of esophageal squamous cell carcinoma, adenocarcinoma of the gastro-esophageal junction and gastric adenocarcinoma. However, several important issues have to be addressed for application in daily diagnostic practice: 1) Validation of prognostic scoring systems for tumor budding in large, multi-center studies 2) Consensus on the optimal assessment method 3) Inter-observer reproducibility. This review provides a comprehensive analysis of TB in cancers of the upper gastrointestinal tract including critical appraisal of perspectives for further study.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00216/fullEpithelial-Mesenchymal TransitionTumor MicroenvironmentSquamous cell carcinomapersonalized medicineesophageal cancergastric cancer |
| spellingShingle | Viktor Hendrik Koelzer Rupert eLanger Inti eZlobec Alessandro eLugli Tumor budding in upper gastrointestinal carcinomas Frontiers in Oncology Epithelial-Mesenchymal Transition Tumor Microenvironment Squamous cell carcinoma personalized medicine esophageal cancer gastric cancer |
| title | Tumor budding in upper gastrointestinal carcinomas |
| title_full | Tumor budding in upper gastrointestinal carcinomas |
| title_fullStr | Tumor budding in upper gastrointestinal carcinomas |
| title_full_unstemmed | Tumor budding in upper gastrointestinal carcinomas |
| title_short | Tumor budding in upper gastrointestinal carcinomas |
| title_sort | tumor budding in upper gastrointestinal carcinomas |
| topic | Epithelial-Mesenchymal Transition Tumor Microenvironment Squamous cell carcinoma personalized medicine esophageal cancer gastric cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00216/full |
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