The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia
Muluken Walle,1 Fasil Getu,1 Yemataw Gelaw,2 Zegeye Getaneh2 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Jigjiga University, Jijiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-10-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/the-diagnostic-value-of-hepatic-and-renal-biochemical-tests-for-the-de-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1828343884256641024 |
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| author | Walle M Getu F Gelaw Y Getaneh Z |
| author_facet | Walle M Getu F Gelaw Y Getaneh Z |
| author_sort | Walle M |
| collection | DOAJ |
| description | Muluken Walle,1 Fasil Getu,1 Yemataw Gelaw,2 Zegeye Getaneh2 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Jigjiga University, Jijiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Muluken Walle, Email muluken.walle23@gmail.comBackground: Preeclampsia has a deleterious effect on renal and liver function, which results in alterations of various biochemical tests. Therefore, the main aim of this study was to evaluate the role of some hepatic and renal biochemical tests in the diagnosis of preeclampsia.Methods: A comparative cross-sectional study was carried out on a total of 126 pregnant women after 20th week of gestation who attended at the University of Gondar Comprehensive Specialized Hospital. The participants were divided into two groups as cases and controls. The case group consisted of 63 preeclamptic women, whereas the control group had 63 age and gestational week matched normotensive pregnant women. From each participant, three milliliters of blood was collected, the serum part was separated, and selected biochemical tests were measured using Humastar 800 chemistry analyzer. An independent t-test and receiver operating characteristics were done using SPSS 20 for comparison and diagnostic value determination of different biochemical tests between the study groups.Results: The maternal serum aminotransferases, total bilirubin, Creatinine, and Urea levels were all significantly elevated in preeclamptic women compared to normotensive pregnant women. The receiver operating characteristics plots revealed that serum aspartate aminotransferase level had area under the curve of 0.89 (95% CI: 0.84– 0.95) and can distinguish preeclampsia patients from normotensive pregnant women at cut-off value of ≥ 58.5 U/l with 74.6% sensitivity, 87.3% specificity, and 80.9% diagnostic accuracy. Serum Creatinine level had area under the curve of 0.91 (95% CI: 0.86– 0.96), which enabled to indicate preeclampsia at a cut-off value ≥ 0.90 mg/dl with 77.8% sensitivity and 85.7% specificity.Conclusion: An increased serum aminotransferases, total bilirubin, creatinine, and Urea levels in pregnant women could indicate the development of preeclampsia, and needs to be investigated. Among biochemical tests, serum Creatinine level was the best diagnostic marker of preeclampsia, followed by serum aspartate aminotransferase level.Keywords: hepatic test, renal test, biochemical test, pregnancy, preeclampsia |
| first_indexed | 2024-04-13T23:48:45Z |
| format | Article |
| id | doaj.art-29c7f586d0594b568bcc57bb3090c057 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T23:48:45Z |
| publishDate | 2022-10-01 |
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| series | International Journal of General Medicine |
| spelling | doaj.art-29c7f586d0594b568bcc57bb3090c0572022-12-22T02:24:12ZengDove Medical PressInternational Journal of General Medicine1178-70742022-10-01Volume 157761777178855The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest EthiopiaWalle MGetu FGelaw YGetaneh ZMuluken Walle,1 Fasil Getu,1 Yemataw Gelaw,2 Zegeye Getaneh2 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Jigjiga University, Jijiga, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Muluken Walle, Email muluken.walle23@gmail.comBackground: Preeclampsia has a deleterious effect on renal and liver function, which results in alterations of various biochemical tests. Therefore, the main aim of this study was to evaluate the role of some hepatic and renal biochemical tests in the diagnosis of preeclampsia.Methods: A comparative cross-sectional study was carried out on a total of 126 pregnant women after 20th week of gestation who attended at the University of Gondar Comprehensive Specialized Hospital. The participants were divided into two groups as cases and controls. The case group consisted of 63 preeclamptic women, whereas the control group had 63 age and gestational week matched normotensive pregnant women. From each participant, three milliliters of blood was collected, the serum part was separated, and selected biochemical tests were measured using Humastar 800 chemistry analyzer. An independent t-test and receiver operating characteristics were done using SPSS 20 for comparison and diagnostic value determination of different biochemical tests between the study groups.Results: The maternal serum aminotransferases, total bilirubin, Creatinine, and Urea levels were all significantly elevated in preeclamptic women compared to normotensive pregnant women. The receiver operating characteristics plots revealed that serum aspartate aminotransferase level had area under the curve of 0.89 (95% CI: 0.84– 0.95) and can distinguish preeclampsia patients from normotensive pregnant women at cut-off value of ≥ 58.5 U/l with 74.6% sensitivity, 87.3% specificity, and 80.9% diagnostic accuracy. Serum Creatinine level had area under the curve of 0.91 (95% CI: 0.86– 0.96), which enabled to indicate preeclampsia at a cut-off value ≥ 0.90 mg/dl with 77.8% sensitivity and 85.7% specificity.Conclusion: An increased serum aminotransferases, total bilirubin, creatinine, and Urea levels in pregnant women could indicate the development of preeclampsia, and needs to be investigated. Among biochemical tests, serum Creatinine level was the best diagnostic marker of preeclampsia, followed by serum aspartate aminotransferase level.Keywords: hepatic test, renal test, biochemical test, pregnancy, preeclampsiahttps://www.dovepress.com/the-diagnostic-value-of-hepatic-and-renal-biochemical-tests-for-the-de-peer-reviewed-fulltext-article-IJGMhepatic testrenal testbiochemical testpregnancypreeclampsia |
| spellingShingle | Walle M Getu F Gelaw Y Getaneh Z The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia International Journal of General Medicine hepatic test renal test biochemical test pregnancy preeclampsia |
| title | The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia |
| title_full | The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia |
| title_fullStr | The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia |
| title_full_unstemmed | The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia |
| title_short | The Diagnostic Value of Hepatic and Renal Biochemical Tests for the Detection of Preeclampsia Among Pregnant Women Attending the Antenatal Care Clinic at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia |
| title_sort | diagnostic value of hepatic and renal biochemical tests for the detection of preeclampsia among pregnant women attending the antenatal care clinic at the university of gondar comprehensive specialized hospital gondar northwest ethiopia |
| topic | hepatic test renal test biochemical test pregnancy preeclampsia |
| url | https://www.dovepress.com/the-diagnostic-value-of-hepatic-and-renal-biochemical-tests-for-the-de-peer-reviewed-fulltext-article-IJGM |
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