Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria
Abstract Objective The aim of this study is to determine the prevalence rates of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among hemodialysis (HD) patients as well as to identify associated risk factors. Methodology A multicenter cross-sectio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09177-4 |
| _version_ | 1797266891702534144 |
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| author | Jehan Altinawe Muhammad Eid Akkawi Nihad Kharrat Helu Qusai Hassan Abdul-Hakim Nattouf |
| author_facet | Jehan Altinawe Muhammad Eid Akkawi Nihad Kharrat Helu Qusai Hassan Abdul-Hakim Nattouf |
| author_sort | Jehan Altinawe |
| collection | DOAJ |
| description | Abstract Objective The aim of this study is to determine the prevalence rates of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among hemodialysis (HD) patients as well as to identify associated risk factors. Methodology A multicenter cross-sectional study involved patients who had been on HD for at least three months. The study was conducted at five HD centers in Damascus, Syria from August 2019 to September 2021. HBsAg, HCV-Ab and HIV (antibody/antigen) seropositivity were identified using the third generation ELISA technique. Patients’ information was extracted from their records and by face-to-face interview. Multiple logistic regression models were applied to identify risk factors associated with HBV or HCV seropositivity. The significance level was set at 5%. Results A total of 637 patients were included in the study with a mean age (SD) of 50.5 (15.6) years and 56.7% of them were men. The dialytic age ranged from one to thirty years with a mean (SD) of 6.10 (5.6) years. The prevalence of positive hepatitis B surface antigen, anti-HCV, co-infection of HBV and HCV, and anti-HIV (antibody/antigen) were 3.2%, 22.1%, 0.7%, and 0%, respectively. After controlling for co-variables, hepatitis B vaccine was the only predictor of seropositivity of HBV (OR: 0.15, 95% CI: 0.057–0.393, P < 0.001), as it significantly protected against contracting HBV. On the other hand, the dialytic age (OR: 1.42, 95% CI: 1.12–1.94, P = 0.032) and the dialysis center were significant factors affecting the prevalence of HCV. Conclusions The prevalence of HCV and HBV infections among HD patients in Damascus, Syria has decreased remarkably compared with the results from 2001. Nevertheless, it is still considered relatively high. Thus, there is an urgent need to strengthen the prevention and control measures for viral infection transmission in HD centers in Damascus. |
| first_indexed | 2024-04-25T01:07:54Z |
| format | Article |
| id | doaj.art-29c996d023734d89bf674ec4bfe84787 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-25T01:07:54Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-29c996d023734d89bf674ec4bfe847872024-03-10T12:06:54ZengBMCBMC Infectious Diseases1471-23342024-03-012411810.1186/s12879-024-09177-4Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus SyriaJehan Altinawe0Muhammad Eid Akkawi1Nihad Kharrat Helu2Qusai Hassan3Abdul-Hakim Nattouf4Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus UniversityDepartment of Pharmacy Practice, Faculty of Pharmacy, International Islamic University MalaysiamDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus UniversityDepartment of Internal Medicine, Faculty of Medicine, Damascus UniversityDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus UniversityAbstract Objective The aim of this study is to determine the prevalence rates of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among hemodialysis (HD) patients as well as to identify associated risk factors. Methodology A multicenter cross-sectional study involved patients who had been on HD for at least three months. The study was conducted at five HD centers in Damascus, Syria from August 2019 to September 2021. HBsAg, HCV-Ab and HIV (antibody/antigen) seropositivity were identified using the third generation ELISA technique. Patients’ information was extracted from their records and by face-to-face interview. Multiple logistic regression models were applied to identify risk factors associated with HBV or HCV seropositivity. The significance level was set at 5%. Results A total of 637 patients were included in the study with a mean age (SD) of 50.5 (15.6) years and 56.7% of them were men. The dialytic age ranged from one to thirty years with a mean (SD) of 6.10 (5.6) years. The prevalence of positive hepatitis B surface antigen, anti-HCV, co-infection of HBV and HCV, and anti-HIV (antibody/antigen) were 3.2%, 22.1%, 0.7%, and 0%, respectively. After controlling for co-variables, hepatitis B vaccine was the only predictor of seropositivity of HBV (OR: 0.15, 95% CI: 0.057–0.393, P < 0.001), as it significantly protected against contracting HBV. On the other hand, the dialytic age (OR: 1.42, 95% CI: 1.12–1.94, P = 0.032) and the dialysis center were significant factors affecting the prevalence of HCV. Conclusions The prevalence of HCV and HBV infections among HD patients in Damascus, Syria has decreased remarkably compared with the results from 2001. Nevertheless, it is still considered relatively high. Thus, there is an urgent need to strengthen the prevention and control measures for viral infection transmission in HD centers in Damascus.https://doi.org/10.1186/s12879-024-09177-4HemodialysisInfectionHepatitisHBVHCVHIV |
| spellingShingle | Jehan Altinawe Muhammad Eid Akkawi Nihad Kharrat Helu Qusai Hassan Abdul-Hakim Nattouf Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria BMC Infectious Diseases Hemodialysis Infection Hepatitis HBV HCV HIV |
| title | Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria |
| title_full | Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria |
| title_fullStr | Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria |
| title_full_unstemmed | Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria |
| title_short | Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria |
| title_sort | seroprevalence and risk factors of hbv hcv and hiv among hemodialysis patients a multicenter cross sectional study from damascus syria |
| topic | Hemodialysis Infection Hepatitis HBV HCV HIV |
| url | https://doi.org/10.1186/s12879-024-09177-4 |
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