Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3)

Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3)

Introduction Since the introduction of pneumococcal conjugate vaccines, pneumococcal disease rates have declined for many vaccine-type serotypes. However, serotype 3 (SPN3) continues to cause significant disease and is identified in colonisation epidemiological studies as one of the top circulating...

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Main Authors: Maia Lesosky, Konstantinos Liatsikos, Stephen B Gordon, Kelly Davies, Phoebe Hazenberg, Angela Hyder-Wright, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Daniela M Ferreira, Madlen Farrar, Ashleigh Howard, Andrea M Collins, Jaye Brunning, Hannah Fleet, Amy Bettam, Tinashe Kenny-Nyazika, Dima El Safadi
Format: Article
Language:English
Published: BMJ Publishing Group 2024-01-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/1/e075948.full

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