Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial
Abstract Background Impulsivity is a core feature of borderline personality disorder (BPD) and is closely related to suicide risk and destructive and aggressive behaviors. Although transcranial direct current stimulation (tDCS) has shown its promising effects as an intervention to modulate impulsivi...
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-019-3427-z |
| _version_ | 1818172046830469120 |
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| author | Juliana Teti Mayer Magali Nicolier Damien Gabriel Caroline Masse Julie Giustiniani Charline Compagne Pierre Vandel Lionel Pazart Emmanuel Haffen Djamila Bennabi |
| author_facet | Juliana Teti Mayer Magali Nicolier Damien Gabriel Caroline Masse Julie Giustiniani Charline Compagne Pierre Vandel Lionel Pazart Emmanuel Haffen Djamila Bennabi |
| author_sort | Juliana Teti Mayer |
| collection | DOAJ |
| description | Abstract Background Impulsivity is a core feature of borderline personality disorder (BPD) and is closely related to suicide risk and destructive and aggressive behaviors. Although transcranial direct current stimulation (tDCS) has shown its promising effects as an intervention to modulate impulsivity, no study has explored its potential regarding BPD. Methods/design This is a multicenter, crossover, double-blind study comparing active versus sham tDCS (2 mA, 30 min), applied over the dorsolateral prefrontal cortex for five consecutive days in 50 BPD patients. Participants will be assessed for impulsivity, depressive symptoms, and suicide risk. The main efficacy criteria on reduction of impulsivity will be the amplitude variation of one specific evoked potential detected by electroencephalography (EEG) during the balloon analogue risk task. Baseline measures will be compared to scores obtained immediately after sessions, then 12 and 30 days later. Discussion This study investigates the safety and effects of tDCS, which may have a significant impact on impulsivity in patients with BPD and may be useful to reduce risky behaviors. Trial registration ClinicalTrials.gov, NCT03498937. Registered on 17 April 2018. |
| first_indexed | 2024-12-11T19:06:23Z |
| format | Article |
| id | doaj.art-29ca0170f41f4e58925a670b526b11aa |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-11T19:06:23Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-29ca0170f41f4e58925a670b526b11aa2022-12-22T00:53:52ZengBMCTrials1745-62152019-06-012011710.1186/s13063-019-3427-zEfficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trialJuliana Teti Mayer0Magali Nicolier1Damien Gabriel2Caroline Masse3Julie Giustiniani4Charline Compagne5Pierre Vandel6Lionel Pazart7Emmanuel Haffen8Djamila Bennabi9Service de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonCentre d’Investigation Clinique, INSERM CIC 1431, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonCentre d’Investigation Clinique, INSERM CIC 1431, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonCentre d’Investigation Clinique, INSERM CIC 1431, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonService de Psychiatrie de l’Adulte, Centre Hospitalier Universitaire de BesançonAbstract Background Impulsivity is a core feature of borderline personality disorder (BPD) and is closely related to suicide risk and destructive and aggressive behaviors. Although transcranial direct current stimulation (tDCS) has shown its promising effects as an intervention to modulate impulsivity, no study has explored its potential regarding BPD. Methods/design This is a multicenter, crossover, double-blind study comparing active versus sham tDCS (2 mA, 30 min), applied over the dorsolateral prefrontal cortex for five consecutive days in 50 BPD patients. Participants will be assessed for impulsivity, depressive symptoms, and suicide risk. The main efficacy criteria on reduction of impulsivity will be the amplitude variation of one specific evoked potential detected by electroencephalography (EEG) during the balloon analogue risk task. Baseline measures will be compared to scores obtained immediately after sessions, then 12 and 30 days later. Discussion This study investigates the safety and effects of tDCS, which may have a significant impact on impulsivity in patients with BPD and may be useful to reduce risky behaviors. Trial registration ClinicalTrials.gov, NCT03498937. Registered on 17 April 2018.http://link.springer.com/article/10.1186/s13063-019-3427-zBorderline personality disorderTranscranial direct current stimulationImpulsivityRisk-takingDorsolateral prefrontal cortex |
| spellingShingle | Juliana Teti Mayer Magali Nicolier Damien Gabriel Caroline Masse Julie Giustiniani Charline Compagne Pierre Vandel Lionel Pazart Emmanuel Haffen Djamila Bennabi Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial Trials Borderline personality disorder Transcranial direct current stimulation Impulsivity Risk-taking Dorsolateral prefrontal cortex |
| title | Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial |
| title_full | Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial |
| title_fullStr | Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial |
| title_full_unstemmed | Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial |
| title_short | Efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder (TIMBER): study protocol of a randomized controlled clinical trial |
| title_sort | efficacy of transcranial direct current stimulation in reducing impulsivity in borderline personality disorder timber study protocol of a randomized controlled clinical trial |
| topic | Borderline personality disorder Transcranial direct current stimulation Impulsivity Risk-taking Dorsolateral prefrontal cortex |
| url | http://link.springer.com/article/10.1186/s13063-019-3427-z |
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