Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-03-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/10/3/02-0821_article |
| _version_ | 1818326065339170816 |
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| author | Chunyan Ye Joseph B. Prescott Robert A. Nofchissey Diane Goade Brian Hjelle |
| author_facet | Chunyan Ye Joseph B. Prescott Robert A. Nofchissey Diane Goade Brian Hjelle |
| author_sort | Chunyan Ye |
| collection | DOAJ |
| description | Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection. |
| first_indexed | 2024-12-13T11:54:27Z |
| format | Article |
| id | doaj.art-29cb9e790ef64c6e963260acf8cfca76 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-13T11:54:27Z |
| publishDate | 2004-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-29cb9e790ef64c6e963260acf8cfca762022-12-21T23:47:16ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-03-0110347848210.3201/eid1003.020821Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary SyndromeChunyan YeJoseph B. PrescottRobert A. NofchisseyDiane GoadeBrian HjellePatients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection.https://wwwnc.cdc.gov/eid/article/10/3/02-0821_articlehantavirusSin Nombre virushantavirus cardiopulmonary syndromepersistenceHCPSneutralizing antibody |
| spellingShingle | Chunyan Ye Joseph B. Prescott Robert A. Nofchissey Diane Goade Brian Hjelle Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome Emerging Infectious Diseases hantavirus Sin Nombre virus hantavirus cardiopulmonary syndrome persistence HCPS neutralizing antibody |
| title | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
| title_full | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
| title_fullStr | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
| title_full_unstemmed | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
| title_short | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
| title_sort | neutralizing antibodies and sin nombre virus rna after recovery from hantavirus cardiopulmonary syndrome |
| topic | hantavirus Sin Nombre virus hantavirus cardiopulmonary syndrome persistence HCPS neutralizing antibody |
| url | https://wwwnc.cdc.gov/eid/article/10/3/02-0821_article |
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