A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is one of the most devastating types of stroke. This study aims to develop a new drug carrier with hematoma-specific response and high property. pH-sensitive liposomes (PSL) were developed. Fingolimod with ammonia borane were encapsulated in the phospholipid vesicles t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-11-01
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| Series: | Nanophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/nanoph-2022-0496 |
| _version_ | 1797788991973490688 |
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| author | Gong Xiyu Fan Xingyu He Yongju Wang Yingwei Zhou Fangfang Yang Binbin |
| author_facet | Gong Xiyu Fan Xingyu He Yongju Wang Yingwei Zhou Fangfang Yang Binbin |
| author_sort | Gong Xiyu |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) is one of the most devastating types of stroke. This study aims to develop a new drug carrier with hematoma-specific response and high property. pH-sensitive liposomes (PSL) were developed. Fingolimod with ammonia borane were encapsulated in the phospholipid vesicles to integrate two drugs for treating ICH more effectively. pH sensitive PSL-FTY720/AB was characterized for various physicochemical parameters such as shape, surface morphology, vesicle size, zeta-potential, in-vitro drug release in different pH environment, cellular toxicity, in-vivo and ex-vivo tissue accumulation. In vivo results further confirmed that drug-loading nanoparticles effectively protected against ICH-induced brain injury through synergistic effect of anti-inflammation and anti-oxidation. Collectively, the present study confirmed that PSL-FTY720/AB can be an effective, safe, and a novel alternative treatment approach in ICH. |
| first_indexed | 2024-03-13T01:44:26Z |
| format | Article |
| id | doaj.art-29cc812f55c84f5da31d6d92c424c23e |
| institution | Directory Open Access Journal |
| issn | 2192-8606 2192-8614 |
| language | English |
| last_indexed | 2024-03-13T01:44:26Z |
| publishDate | 2022-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj.art-29cc812f55c84f5da31d6d92c424c23e2023-07-03T10:20:08ZengDe GruyterNanophotonics2192-86062192-86142022-11-0111225133514210.1515/nanoph-2022-0496A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhageGong Xiyu0Fan Xingyu1He Yongju2Wang Yingwei3Zhou Fangfang4Yang Binbin5Department of neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan410011, ChinaSchool of Materials Science and Engineering, Central South University, Changsha, Hunan410083, ChinaSchool of Materials Science and Engineering, Central South University, Changsha, Hunan410083, ChinaHunan Key Laboratory of Nanophotonics and Divices, Central South University, Changsha, Hunan410083, ChinaDepartment of neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan410011, ChinaDepartment of neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan410011, ChinaIntracerebral hemorrhage (ICH) is one of the most devastating types of stroke. This study aims to develop a new drug carrier with hematoma-specific response and high property. pH-sensitive liposomes (PSL) were developed. Fingolimod with ammonia borane were encapsulated in the phospholipid vesicles to integrate two drugs for treating ICH more effectively. pH sensitive PSL-FTY720/AB was characterized for various physicochemical parameters such as shape, surface morphology, vesicle size, zeta-potential, in-vitro drug release in different pH environment, cellular toxicity, in-vivo and ex-vivo tissue accumulation. In vivo results further confirmed that drug-loading nanoparticles effectively protected against ICH-induced brain injury through synergistic effect of anti-inflammation and anti-oxidation. Collectively, the present study confirmed that PSL-FTY720/AB can be an effective, safe, and a novel alternative treatment approach in ICH.https://doi.org/10.1515/nanoph-2022-0496ammonia boranefingolimodintracerebral hemorrhageliposome |
| spellingShingle | Gong Xiyu Fan Xingyu He Yongju Wang Yingwei Zhou Fangfang Yang Binbin A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage Nanophotonics ammonia borane fingolimod intracerebral hemorrhage liposome |
| title | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| title_full | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| title_fullStr | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| title_full_unstemmed | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| title_short | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| title_sort | ph sensitive liposomal co delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
| topic | ammonia borane fingolimod intracerebral hemorrhage liposome |
| url | https://doi.org/10.1515/nanoph-2022-0496 |
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