Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers
Breast cancers are commonly associated with an immunosuppressive microenvironment responsible for tumor escape from anti-cancer immunity. Cells of the myeloid lineage account for a major part of this tumor-promoting landscape. These myeloid cells are composed of heterogeneous subsets at different st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.838040/full |
| _version_ | 1818199804700786688 |
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| author | Céline Blaye Céline Blaye Thomas Boyer Florent Peyraud Charlotte Domblides Charlotte Domblides Nicolas Larmonier Nicolas Larmonier |
| author_facet | Céline Blaye Céline Blaye Thomas Boyer Florent Peyraud Charlotte Domblides Charlotte Domblides Nicolas Larmonier Nicolas Larmonier |
| author_sort | Céline Blaye |
| collection | DOAJ |
| description | Breast cancers are commonly associated with an immunosuppressive microenvironment responsible for tumor escape from anti-cancer immunity. Cells of the myeloid lineage account for a major part of this tumor-promoting landscape. These myeloid cells are composed of heterogeneous subsets at different stages of differentiation and have traditionally been described by their cardinal ability to suppress innate and adaptive anticancer immunity. However, evidence has accumulated that, beyond their immunosuppressive properties, breast cancer-induced myeloid cells are also equipped with a broad array of “non-immunological” tumor-promoting functions. They therefore represent major impediments for anticancer therapies, particularly for immune-based interventions. We herein analyze and discuss current literature related to the versatile properties of the different myeloid cell subsets engaged in breast cancer development. We critically assess persisting difficulties and challenges in unequivocally discriminate dedicated subsets, which has so far prevented both the selective targeting of these immunosuppressive cells and their use as potential biomarkers. In this context, we propose the concept of IMCGL, “pro-tumoral immunosuppressive myeloid cells of the granulocytic lineage”, to more accurately reflect the contentious nature and origin of granulocytic cells in the breast tumor microenvironment. Future research prospects related to the role of this myeloid landscape in breast cancer are further considered. |
| first_indexed | 2024-12-12T02:27:35Z |
| format | Article |
| id | doaj.art-29cd9e45aecc47139b06158bfbbd499f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T02:27:35Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-29cd9e45aecc47139b06158bfbbd499f2022-12-22T00:41:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.838040838040Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast CancersCéline Blaye0Céline Blaye1Thomas Boyer2Florent Peyraud3Charlotte Domblides4Charlotte Domblides5Nicolas Larmonier6Nicolas Larmonier7Centre National de la Recherche Scientific (CNRS) Unité Mixte de Recherche (UMR) 5164, ImmunoConcEpT, Bordeaux, FranceDepartment of Medical Oncology, Institut Bergonié, Bordeaux, FranceCentre National de la Recherche Scientific (CNRS) Unité Mixte de Recherche (UMR) 5164, ImmunoConcEpT, Bordeaux, FranceCentre National de la Recherche Scientific (CNRS) Unité Mixte de Recherche (UMR) 5164, ImmunoConcEpT, Bordeaux, FranceCentre National de la Recherche Scientific (CNRS) Unité Mixte de Recherche (UMR) 5164, ImmunoConcEpT, Bordeaux, FranceService d’Oncologie Médicale, Centre Hospitalo-Universitaire (CHU) Bordeaux, Bordeaux, FranceCentre National de la Recherche Scientific (CNRS) Unité Mixte de Recherche (UMR) 5164, ImmunoConcEpT, Bordeaux, FranceDepartment of Biological and Medical Sciences, University of Bordeaux, Bordeaux, FranceBreast cancers are commonly associated with an immunosuppressive microenvironment responsible for tumor escape from anti-cancer immunity. Cells of the myeloid lineage account for a major part of this tumor-promoting landscape. These myeloid cells are composed of heterogeneous subsets at different stages of differentiation and have traditionally been described by their cardinal ability to suppress innate and adaptive anticancer immunity. However, evidence has accumulated that, beyond their immunosuppressive properties, breast cancer-induced myeloid cells are also equipped with a broad array of “non-immunological” tumor-promoting functions. They therefore represent major impediments for anticancer therapies, particularly for immune-based interventions. We herein analyze and discuss current literature related to the versatile properties of the different myeloid cell subsets engaged in breast cancer development. We critically assess persisting difficulties and challenges in unequivocally discriminate dedicated subsets, which has so far prevented both the selective targeting of these immunosuppressive cells and their use as potential biomarkers. In this context, we propose the concept of IMCGL, “pro-tumoral immunosuppressive myeloid cells of the granulocytic lineage”, to more accurately reflect the contentious nature and origin of granulocytic cells in the breast tumor microenvironment. Future research prospects related to the role of this myeloid landscape in breast cancer are further considered.https://www.frontiersin.org/articles/10.3389/fimmu.2022.838040/fullbreast cancertumor-promoting myeloid cellsimmunosuppressionimmunotherapiestumor microenvironment |
| spellingShingle | Céline Blaye Céline Blaye Thomas Boyer Florent Peyraud Charlotte Domblides Charlotte Domblides Nicolas Larmonier Nicolas Larmonier Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers Frontiers in Immunology breast cancer tumor-promoting myeloid cells immunosuppression immunotherapies tumor microenvironment |
| title | Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers |
| title_full | Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers |
| title_fullStr | Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers |
| title_full_unstemmed | Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers |
| title_short | Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers |
| title_sort | beyond immunosuppression the multifaceted functions of tumor promoting myeloid cells in breast cancers |
| topic | breast cancer tumor-promoting myeloid cells immunosuppression immunotherapies tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.838040/full |
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