Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications
Abstract Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Advers...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01590-x |
| _version_ | 1818428169211871232 |
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| author | Isaac V. Cohen Tigran Makunts Rabia Atayee Ruben Abagyan |
| author_facet | Isaac V. Cohen Tigran Makunts Rabia Atayee Ruben Abagyan |
| author_sort | Isaac V. Cohen |
| collection | DOAJ |
| description | Abstract Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Adverse Effect Reporting System. The results of the examination of population scale data revealed that patients who received ketamine had significantly lower frequency of reports of depression than patients who took any other combination of drugs for pain. The analysis also revealed that patients who took ketamine had significantly lower frequency of reports of pain and opioid induced side effects, implying ketamine’s potential to act as a beneficial adjunct agent in pain management pharmacotherapy. Further, the Inverse-Frequency Analysis methodology provides robust statistical support for the antidepressant action of other currently approved therapeutics including diclofenac and minocycline. |
| first_indexed | 2024-12-14T14:57:21Z |
| format | Article |
| id | doaj.art-29cfb95bdea44b70a57ebcd61bd9f670 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:57:21Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-29cfb95bdea44b70a57ebcd61bd9f6702022-12-21T22:56:58ZengNature PortfolioScientific Reports2045-23222017-05-01711510.1038/s41598-017-01590-xPopulation scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indicationsIsaac V. Cohen0Tigran Makunts1Rabia Atayee2Ruben Abagyan3School of Pharmacy and Pharmaceutical Sciences, University of California San DiegoSchool of Pharmacy and Pharmaceutical Sciences, University of California San DiegoSchool of Pharmacy and Pharmaceutical Sciences, University of California San DiegoSchool of Pharmacy and Pharmaceutical Sciences, University of California San DiegoAbstract Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Adverse Effect Reporting System. The results of the examination of population scale data revealed that patients who received ketamine had significantly lower frequency of reports of depression than patients who took any other combination of drugs for pain. The analysis also revealed that patients who took ketamine had significantly lower frequency of reports of pain and opioid induced side effects, implying ketamine’s potential to act as a beneficial adjunct agent in pain management pharmacotherapy. Further, the Inverse-Frequency Analysis methodology provides robust statistical support for the antidepressant action of other currently approved therapeutics including diclofenac and minocycline.https://doi.org/10.1038/s41598-017-01590-x |
| spellingShingle | Isaac V. Cohen Tigran Makunts Rabia Atayee Ruben Abagyan Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications Scientific Reports |
| title | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications |
| title_full | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications |
| title_fullStr | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications |
| title_full_unstemmed | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications |
| title_short | Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications |
| title_sort | population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non psychiatric indications |
| url | https://doi.org/10.1038/s41598-017-01590-x |
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