Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats
Abstract Background Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has gained attention due to its beneficial effects in control...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-019-0431-0 |
| _version_ | 1819064347050115072 |
|---|---|
| author | Daniela Fernandes Roxo Carlos Alberto Arcaro Vania Ortega Gutierres Mariana Campos Costa Juliana Oriel Oliveira Tayra Ferreira Oliveira Lima Renata Pires Assis Iguatemy Lourenço Brunetti Amanda Martins Baviera |
| author_facet | Daniela Fernandes Roxo Carlos Alberto Arcaro Vania Ortega Gutierres Mariana Campos Costa Juliana Oriel Oliveira Tayra Ferreira Oliveira Lima Renata Pires Assis Iguatemy Lourenço Brunetti Amanda Martins Baviera |
| author_sort | Daniela Fernandes Roxo |
| collection | DOAJ |
| description | Abstract Background Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has gained attention due to its beneficial effects in controlling the disturbances observed in diabetes mellitus. The purpose of this study was to investigate if yoghurt enriched with curcumin and metformin, individually or as mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, and paraoxonase 1 (PON 1) activity in diabetic rats. Methods Streptozotocin-diabetic rats (6-week-old Wistar rats) were treated for 30 days with curcumin and metformin, isolated or as mixtures in yoghurt (10 rats/group). After treatments, the plasma levels of glucose, triacylglycerol, cholesterol, thiobarbituric acid reactive substances (TBARS, a biomarker of lipid oxidation), fluorescent advanced glycation end products (AGEs), and the activity of PON 1, an antioxidant enzyme were assessed. Data were analyzed using one-way analysis of variance (ANOVA) followed by Student–Newman–Keuls test. Results Treatment of diabetic rats with curcumin or metformin alone decreased the plasma levels of glucose, triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as well as increased the activity of PON 1. The combination of metformin with curcumin further decreased dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and maintained the high levels of PON 1. Conclusion These findings indicated that curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels. Therefore, it might be a promising strategy for combating diabetic complications, mainly the cardiovascular events. |
| first_indexed | 2024-12-21T15:29:07Z |
| format | Article |
| id | doaj.art-29d1da06144b44bba221683bca1a9d66 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-21T15:29:07Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-29d1da06144b44bba221683bca1a9d662022-12-21T18:58:49ZengBMCDiabetology & Metabolic Syndrome1758-59962019-04-011111810.1186/s13098-019-0431-0Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic ratsDaniela Fernandes Roxo0Carlos Alberto Arcaro1Vania Ortega Gutierres2Mariana Campos Costa3Juliana Oriel Oliveira4Tayra Ferreira Oliveira Lima5Renata Pires Assis6Iguatemy Lourenço Brunetti7Amanda Martins Baviera8São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical AnalysisAbstract Background Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has gained attention due to its beneficial effects in controlling the disturbances observed in diabetes mellitus. The purpose of this study was to investigate if yoghurt enriched with curcumin and metformin, individually or as mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, and paraoxonase 1 (PON 1) activity in diabetic rats. Methods Streptozotocin-diabetic rats (6-week-old Wistar rats) were treated for 30 days with curcumin and metformin, isolated or as mixtures in yoghurt (10 rats/group). After treatments, the plasma levels of glucose, triacylglycerol, cholesterol, thiobarbituric acid reactive substances (TBARS, a biomarker of lipid oxidation), fluorescent advanced glycation end products (AGEs), and the activity of PON 1, an antioxidant enzyme were assessed. Data were analyzed using one-way analysis of variance (ANOVA) followed by Student–Newman–Keuls test. Results Treatment of diabetic rats with curcumin or metformin alone decreased the plasma levels of glucose, triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as well as increased the activity of PON 1. The combination of metformin with curcumin further decreased dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and maintained the high levels of PON 1. Conclusion These findings indicated that curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels. Therefore, it might be a promising strategy for combating diabetic complications, mainly the cardiovascular events.http://link.springer.com/article/10.1186/s13098-019-0431-0Diabetes mellitusGlycoxidative stressParaoxonaseCurcumin |
| spellingShingle | Daniela Fernandes Roxo Carlos Alberto Arcaro Vania Ortega Gutierres Mariana Campos Costa Juliana Oriel Oliveira Tayra Ferreira Oliveira Lima Renata Pires Assis Iguatemy Lourenço Brunetti Amanda Martins Baviera Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats Diabetology & Metabolic Syndrome Diabetes mellitus Glycoxidative stress Paraoxonase Curcumin |
| title | Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats |
| title_full | Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats |
| title_fullStr | Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats |
| title_full_unstemmed | Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats |
| title_short | Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats |
| title_sort | curcumin combined with metformin decreases glycemia and dyslipidemia and increases paraoxonase activity in diabetic rats |
| topic | Diabetes mellitus Glycoxidative stress Paraoxonase Curcumin |
| url | http://link.springer.com/article/10.1186/s13098-019-0431-0 |
| work_keys_str_mv | AT danielafernandesroxo curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT carlosalbertoarcaro curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT vaniaortegagutierres curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT marianacamposcosta curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT julianaorieloliveira curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT tayraferreiraoliveiralima curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT renatapiresassis curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT iguatemylourencobrunetti curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats AT amandamartinsbaviera curcumincombinedwithmetformindecreasesglycemiaanddyslipidemiaandincreasesparaoxonaseactivityindiabeticrats |