Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications
Electrospinning is a simple, cost-effective technique and a reproducible process for both synthetic and natural polymers. It is found to be an attractive tool for various applications in biomedical engineering, filtration, protective clothing, catalysis reactions and sensors. Non-ionic cellulose eth...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893924000574 |
| _version_ | 1827215294205001728 |
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| author | Ashwini Wali Mahadeo Gorain Gopal Kundu Manohar Badiger |
| author_facet | Ashwini Wali Mahadeo Gorain Gopal Kundu Manohar Badiger |
| author_sort | Ashwini Wali |
| collection | DOAJ |
| description | Electrospinning is a simple, cost-effective technique and a reproducible process for both synthetic and natural polymers. It is found to be an attractive tool for various applications in biomedical engineering, filtration, protective clothing, catalysis reactions and sensors. Non-ionic cellulose ethers namely Ethyl Hydroxy Ethyl Cellulose (EHEC) is an important polysaccharide which is non-toxic, biocompatible and biodegradable and finds applications as thickening/rheology control agents in paints, cosmetics, detergents, oil recovery and also in the biomedical area. Poly (vinyl alcohol) (PVA) is a semi-crystalline hydrophilic polymer which is highly biocompatible and non-toxic having good thermal and mechanical properties and also high water solubility. Silver shows powerful antimicrobial activity and is non-toxic. It has been used to cure severe burns and chronic ulcers for many decades and is extensively used as an additive in various fields like prostheses, burn treatment, catheters, vascular grafts, dental resin components, ion exchange fibers, stainless steel materials, human skin and coating of medical devices. In the present work, EHEC/PVA nanofibers embedded with silver nanoparticles (AgNPs) are studied for their antibacterial activity using both gram positive and gram negative bacteria. The nanofibers show increase in tensile properties with the addition of silver nano-particles. The AgNPs embedded EHEC/PVA nanofiber mats having 0.5% AgNPs were found to enhance the wound healing with no scar formation in wistar rats. The biological in-vitro and in-vivo studies support the potential of EHEC based nanofibers as excellent bio-materials for the treatment of severe burns and wounds. To the best of our knowledge, this is the first report on the electrospinning of EHEC/PVA nanofibers for wound healing applications. |
| first_indexed | 2024-04-24T23:23:35Z |
| format | Article |
| id | doaj.art-29d23c39f18542ec8288824266077e52 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2025-03-21T14:44:56Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-29d23c39f18542ec8288824266077e522024-06-21T08:57:37ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-06-017100477Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applicationsAshwini Wali0Mahadeo Gorain1Gopal Kundu2Manohar Badiger3Department of Chemical Engineering, M S Ramaiah Institute of Technology, Bangalore, Karnataka, India; Department of Polymer science and Engineering, CSIR-National Chemical Laboratory, Pune, Maharashtra, India; Corresponding author.Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre, for Cell Science, Pune, 411007, Maharashtra, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre, for Cell Science, Pune, 411007, Maharashtra, India; School of Biotechnology and Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Institute of Eminence, Bhubaneswar 751 024, IndiaDepartment of Polymer science and Engineering, CSIR-National Chemical Laboratory, Pune, Maharashtra, IndiaElectrospinning is a simple, cost-effective technique and a reproducible process for both synthetic and natural polymers. It is found to be an attractive tool for various applications in biomedical engineering, filtration, protective clothing, catalysis reactions and sensors. Non-ionic cellulose ethers namely Ethyl Hydroxy Ethyl Cellulose (EHEC) is an important polysaccharide which is non-toxic, biocompatible and biodegradable and finds applications as thickening/rheology control agents in paints, cosmetics, detergents, oil recovery and also in the biomedical area. Poly (vinyl alcohol) (PVA) is a semi-crystalline hydrophilic polymer which is highly biocompatible and non-toxic having good thermal and mechanical properties and also high water solubility. Silver shows powerful antimicrobial activity and is non-toxic. It has been used to cure severe burns and chronic ulcers for many decades and is extensively used as an additive in various fields like prostheses, burn treatment, catheters, vascular grafts, dental resin components, ion exchange fibers, stainless steel materials, human skin and coating of medical devices. In the present work, EHEC/PVA nanofibers embedded with silver nanoparticles (AgNPs) are studied for their antibacterial activity using both gram positive and gram negative bacteria. The nanofibers show increase in tensile properties with the addition of silver nano-particles. The AgNPs embedded EHEC/PVA nanofiber mats having 0.5% AgNPs were found to enhance the wound healing with no scar formation in wistar rats. The biological in-vitro and in-vivo studies support the potential of EHEC based nanofibers as excellent bio-materials for the treatment of severe burns and wounds. To the best of our knowledge, this is the first report on the electrospinning of EHEC/PVA nanofibers for wound healing applications.http://www.sciencedirect.com/science/article/pii/S2666893924000574Silver nanoparticle synthesisElectrospinning nanofibersBurn wound dressingEthyl hydroxy ethyl cellulosePoly vinyl alcoholNo scar formation |
| spellingShingle | Ashwini Wali Mahadeo Gorain Gopal Kundu Manohar Badiger Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications Carbohydrate Polymer Technologies and Applications Silver nanoparticle synthesis Electrospinning nanofibers Burn wound dressing Ethyl hydroxy ethyl cellulose Poly vinyl alcohol No scar formation |
| title | Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications |
| title_full | Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications |
| title_fullStr | Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications |
| title_full_unstemmed | Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications |
| title_short | Silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: Synthesis, characterization and wound dressing applications |
| title_sort | silver nanoparticles in electrospun ethyl hydroxy ethyl cellulose pva nanofiber synthesis characterization and wound dressing applications |
| topic | Silver nanoparticle synthesis Electrospinning nanofibers Burn wound dressing Ethyl hydroxy ethyl cellulose Poly vinyl alcohol No scar formation |
| url | http://www.sciencedirect.com/science/article/pii/S2666893924000574 |
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