A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients.
Inconsistent associations with warfarin dose were observed in genetic variants except VKORC1 haplotype and CYP2C9*3 in Chinese people, and few studies on warfarin dose algorithm was performed in a large Chinese Han population lived in Northern China. Of 787 consenting patients with heart-valve repla...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4134280?pdf=render |
| _version_ | 1818238981089787904 |
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| author | Jinxing Chen Liying Shao Ling Gong Fang Luo Jin'e Wang Yi Shi Yu Tan Qianlong Chen Yu Zhang Rutai Hui Yibo Wang |
| author_facet | Jinxing Chen Liying Shao Ling Gong Fang Luo Jin'e Wang Yi Shi Yu Tan Qianlong Chen Yu Zhang Rutai Hui Yibo Wang |
| author_sort | Jinxing Chen |
| collection | DOAJ |
| description | Inconsistent associations with warfarin dose were observed in genetic variants except VKORC1 haplotype and CYP2C9*3 in Chinese people, and few studies on warfarin dose algorithm was performed in a large Chinese Han population lived in Northern China. Of 787 consenting patients with heart-valve replacements who were receiving long-term warfarin maintenance therapy, 20 related Single nucleotide polymorphisms were genotyped. Only VKORC1 and CYP2C9 SNPs were observed to be significantly associated with warfarin dose. In the derivation cohort (n = 551), warfarin dose variability was influenced, in decreasing order, by VKORC1 rs7294 (27.3%), CYP2C9*3(7.0%), body surface area(4.2%), age(2.7%), target INR(1.4%), CYP4F2 rs2108622 (0.7%), amiodarone use(0.6%), diabetes mellitus(0.6%), and digoxin use(0.5%), which account for 45.1% of the warfarin dose variability. In the validation cohort (n = 236), the actual maintenance dose was significantly correlated with predicted dose (r = 0.609, P<0.001). Our algorithm could improve the personalized management of warfarin use in Northern Chinese patients. |
| first_indexed | 2024-12-12T12:50:17Z |
| format | Article |
| id | doaj.art-29d508fabeee4b679a775c9fd1fa2489 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T12:50:17Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-29d508fabeee4b679a775c9fd1fa24892022-12-22T00:24:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10525010.1371/journal.pone.0105250A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients.Jinxing ChenLiying ShaoLing GongFang LuoJin'e WangYi ShiYu TanQianlong ChenYu ZhangRutai HuiYibo WangInconsistent associations with warfarin dose were observed in genetic variants except VKORC1 haplotype and CYP2C9*3 in Chinese people, and few studies on warfarin dose algorithm was performed in a large Chinese Han population lived in Northern China. Of 787 consenting patients with heart-valve replacements who were receiving long-term warfarin maintenance therapy, 20 related Single nucleotide polymorphisms were genotyped. Only VKORC1 and CYP2C9 SNPs were observed to be significantly associated with warfarin dose. In the derivation cohort (n = 551), warfarin dose variability was influenced, in decreasing order, by VKORC1 rs7294 (27.3%), CYP2C9*3(7.0%), body surface area(4.2%), age(2.7%), target INR(1.4%), CYP4F2 rs2108622 (0.7%), amiodarone use(0.6%), diabetes mellitus(0.6%), and digoxin use(0.5%), which account for 45.1% of the warfarin dose variability. In the validation cohort (n = 236), the actual maintenance dose was significantly correlated with predicted dose (r = 0.609, P<0.001). Our algorithm could improve the personalized management of warfarin use in Northern Chinese patients.http://europepmc.org/articles/PMC4134280?pdf=render |
| spellingShingle | Jinxing Chen Liying Shao Ling Gong Fang Luo Jin'e Wang Yi Shi Yu Tan Qianlong Chen Yu Zhang Rutai Hui Yibo Wang A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. PLoS ONE |
| title | A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. |
| title_full | A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. |
| title_fullStr | A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. |
| title_full_unstemmed | A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. |
| title_short | A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. |
| title_sort | pharmacogenetics based warfarin maintenance dosing algorithm from northern chinese patients |
| url | http://europepmc.org/articles/PMC4134280?pdf=render |
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