Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B
Radmila Karpova,1 Andrey Gorbunov,1 Marina Mnatsakanyan,2 Aleksandr Pogromov,2 Irina Sokolova,2 Yuliya Shumskaya,2 Ksenia Russkova,3 Kirill Chernousov,1 Daria Momatyuk3 1Department of Faculty Surgery No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechen...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-06-01
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| Series: | Journal of Blood Medicine |
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| Online Access: | https://www.dovepress.com/emergency-splenectomy-in-a-patient-with-splenic-marginal-zone-lymphoma-peer-reviewed-fulltext-article-JBM |
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| author | Karpova R Gorbunov A Mnatsakanyan M Pogromov A Sokolova I Shumskaya Y Russkova K Chernousov K Momatyuk D |
| author_facet | Karpova R Gorbunov A Mnatsakanyan M Pogromov A Sokolova I Shumskaya Y Russkova K Chernousov K Momatyuk D |
| author_sort | Karpova R |
| collection | DOAJ |
| description | Radmila Karpova,1 Andrey Gorbunov,1 Marina Mnatsakanyan,2 Aleksandr Pogromov,2 Irina Sokolova,2 Yuliya Shumskaya,2 Ksenia Russkova,3 Kirill Chernousov,1 Daria Momatyuk3 1Department of Faculty Surgery No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 2Department of Hospital Therapy No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 3Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaCorrespondence: Ksenia RusskovaInstitute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya st, Moscow, 119991, RussiaTel +79050164054Email russkova.ksy@gmail.comAbstract: Splenic marginal zone lymphoma (SMZL) is a type of non-Hodgkin’s lymphoma (NL) that occurs in 2 out of 100 cases and is more common in women aged > 60 years. A sluggish, asymptomatic course of the disease does not exclude transformation into a malignant form that occurs in 25% of patients with SMZL. Another equally important sign of an NL is thrombosis that occurs in 3.6% to 17.1% of the cases. In this report, we present a case of emergency splenectomy in a patient owing to difficulties in the diagnosis of SMZL, rapid onset of acute portal vein thrombosis, and the fulminant enlargement of the spleen accompanied by an increased risk of its rupture. Chronic hepatitis B was likely the trigger for transformation of the disease to an aggressive course. Portal vein thrombosis and the aggressive course of SMZL with rapid enlargement of the spleen and threat of its rupture in the background of viral hepatitis B required emergency splenectomy followed by anticoagulant, antiviral, and antitumor therapy.Keywords: splenic marginal zone lymphoma, SMZL, portal vein thrombosis, emergency splenectomy, chronic viral hepatitis B |
| first_indexed | 2024-12-17T01:41:55Z |
| format | Article |
| id | doaj.art-29d69ad1fd45415cb20a661d335929e6 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-17T01:41:55Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-29d69ad1fd45415cb20a661d335929e62022-12-21T22:08:18ZengDove Medical PressJournal of Blood Medicine1179-27362021-06-01Volume 1243143465686Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis BKarpova RGorbunov AMnatsakanyan MPogromov ASokolova IShumskaya YRusskova KChernousov KMomatyuk DRadmila Karpova,1 Andrey Gorbunov,1 Marina Mnatsakanyan,2 Aleksandr Pogromov,2 Irina Sokolova,2 Yuliya Shumskaya,2 Ksenia Russkova,3 Kirill Chernousov,1 Daria Momatyuk3 1Department of Faculty Surgery No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 2Department of Hospital Therapy No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 3Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaCorrespondence: Ksenia RusskovaInstitute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya st, Moscow, 119991, RussiaTel +79050164054Email russkova.ksy@gmail.comAbstract: Splenic marginal zone lymphoma (SMZL) is a type of non-Hodgkin’s lymphoma (NL) that occurs in 2 out of 100 cases and is more common in women aged > 60 years. A sluggish, asymptomatic course of the disease does not exclude transformation into a malignant form that occurs in 25% of patients with SMZL. Another equally important sign of an NL is thrombosis that occurs in 3.6% to 17.1% of the cases. In this report, we present a case of emergency splenectomy in a patient owing to difficulties in the diagnosis of SMZL, rapid onset of acute portal vein thrombosis, and the fulminant enlargement of the spleen accompanied by an increased risk of its rupture. Chronic hepatitis B was likely the trigger for transformation of the disease to an aggressive course. Portal vein thrombosis and the aggressive course of SMZL with rapid enlargement of the spleen and threat of its rupture in the background of viral hepatitis B required emergency splenectomy followed by anticoagulant, antiviral, and antitumor therapy.Keywords: splenic marginal zone lymphoma, SMZL, portal vein thrombosis, emergency splenectomy, chronic viral hepatitis Bhttps://www.dovepress.com/emergency-splenectomy-in-a-patient-with-splenic-marginal-zone-lymphoma-peer-reviewed-fulltext-article-JBMsplenic marginal zone lymphoma (smzl)portal vein thrombosisemergency splenectomychronic viral hepatitis b |
| spellingShingle | Karpova R Gorbunov A Mnatsakanyan M Pogromov A Sokolova I Shumskaya Y Russkova K Chernousov K Momatyuk D Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B Journal of Blood Medicine splenic marginal zone lymphoma (smzl) portal vein thrombosis emergency splenectomy chronic viral hepatitis b |
| title | Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B |
| title_full | Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B |
| title_fullStr | Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B |
| title_full_unstemmed | Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B |
| title_short | Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B |
| title_sort | emergency splenectomy in a patient with splenic marginal zone lymphoma acute portal vein thrombosis and chronic viral hepatitis b |
| topic | splenic marginal zone lymphoma (smzl) portal vein thrombosis emergency splenectomy chronic viral hepatitis b |
| url | https://www.dovepress.com/emergency-splenectomy-in-a-patient-with-splenic-marginal-zone-lymphoma-peer-reviewed-fulltext-article-JBM |
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