Long-Term Protection Elicited by a DNA Vaccine Candidate Expressing the prM-E Antigen of Dengue Virus Serotype 3 in Mice

Long-Term Protection Elicited by a DNA Vaccine Candidate Expressing the prM-E Antigen of Dengue Virus Serotype 3 in Mice

Dengue virus (DENV) is the causative agent of dengue, and its incidence has increased 30-fold in the past five decades. Among the four cocirculating serotypes, DENV3 is associated with an increased number of severe infections and has become widespread. Vaccination is the mainstay of prevention in re...

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Bibliographic Details
Main Authors: Kaihao Feng, Xiaoyan Zheng, Ran Wang, Na Gao, Dongying Fan, Ziyang Sheng, Hongning Zhou, Hui Chen, Jing An
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
dengue virus
DNA vaccine
prM-E
immunization
cross-protection
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00087/full

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