Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells
Abstract. GATA2, a principal member of the GATA family, plays important roles in the generation and maintenance of hematopoietic stem/progenitor cells. Among the three mRNA transcripts, the distal first exon of GATA2 (IS exon) is specific for hematopoietic and neuronal cells. GATA2 mutants with abno...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2020-01-01
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| Series: | Blood Science |
| Online Access: | http://journals.lww.com/10.1097/BS9.0000000000000040 |
| _version_ | 1818774892347129856 |
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| author | Ya Zhou Bin Mao Yijin Chen Yuan Xue Bo Chen Yonggang Zhang Feng Ma |
| author_facet | Ya Zhou Bin Mao Yijin Chen Yuan Xue Bo Chen Yonggang Zhang Feng Ma |
| author_sort | Ya Zhou |
| collection | DOAJ |
| description | Abstract. GATA2, a principal member of the GATA family, plays important roles in the generation and maintenance of hematopoietic stem/progenitor cells. Among the three mRNA transcripts, the distal first exon of GATA2 (IS exon) is specific for hematopoietic and neuronal cells. GATA2 mutants with abnormal expression are often present in acute myeloid leukemia-related familial diseases and myelodysplastic syndrome, indicating the crucial significance of GATA2 in the proper maintenance of blood system functions. This article offers an overview of the regulation dynamics and function of GATA2 in the generation, proliferation, and function of hematopoietic stem cells in both mouse and human models. We acknowledge the current progress in the cell fate determination mechanism by dynamic GATA2 expression. The gene modification approaches for inspecting the role of GATA2 in definitive hematopoiesis demonstrate the potential for acquiring hPSC-derived hematopoietic stem cells via manipulated GATA2 regulation. |
| first_indexed | 2024-12-18T10:48:22Z |
| format | Article |
| id | doaj.art-29d96e41ab9440c4a41c2b2cfe56dbfc |
| institution | Directory Open Access Journal |
| issn | 2543-6368 |
| language | English |
| last_indexed | 2024-12-18T10:48:22Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Blood Science |
| spelling | doaj.art-29d96e41ab9440c4a41c2b2cfe56dbfc2022-12-21T21:10:31ZengWolters Kluwer HealthBlood Science2543-63682020-01-01211610.1097/BS9.0000000000000040202001000-00001Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cellsYa ZhouBin MaoYijin ChenYuan XueBo ChenYonggang ZhangFeng MaAbstract. GATA2, a principal member of the GATA family, plays important roles in the generation and maintenance of hematopoietic stem/progenitor cells. Among the three mRNA transcripts, the distal first exon of GATA2 (IS exon) is specific for hematopoietic and neuronal cells. GATA2 mutants with abnormal expression are often present in acute myeloid leukemia-related familial diseases and myelodysplastic syndrome, indicating the crucial significance of GATA2 in the proper maintenance of blood system functions. This article offers an overview of the regulation dynamics and function of GATA2 in the generation, proliferation, and function of hematopoietic stem cells in both mouse and human models. We acknowledge the current progress in the cell fate determination mechanism by dynamic GATA2 expression. The gene modification approaches for inspecting the role of GATA2 in definitive hematopoiesis demonstrate the potential for acquiring hPSC-derived hematopoietic stem cells via manipulated GATA2 regulation.http://journals.lww.com/10.1097/BS9.0000000000000040 |
| spellingShingle | Ya Zhou Bin Mao Yijin Chen Yuan Xue Bo Chen Yonggang Zhang Feng Ma Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells Blood Science |
| title | Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells |
| title_full | Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells |
| title_fullStr | Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells |
| title_full_unstemmed | Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells |
| title_short | Dynamic regulation of GATA2 in fate determination in hematopoiesis: possible approach to hPSC-derived hematopoietic stem/progenitor cells |
| title_sort | dynamic regulation of gata2 in fate determination in hematopoiesis possible approach to hpsc derived hematopoietic stem progenitor cells |
| url | http://journals.lww.com/10.1097/BS9.0000000000000040 |
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