VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges

VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage dependent anion channels (VDAC). The closed states...

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Bibliographic Details
Main Authors: Kareem A. Heslop, Veronica Milesi, Eduardo N. Maldonado
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
cancer
glycolysis
metabolic flexibility
metabolic reprogramming
metabolism
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.742839/full

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