Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound
<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to evaluate the mechanical properties of coronary plaques and plaque behavior, and to elucidate the relationship among tissue characteristics of coronary plaques, mechanical properties and coronar...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | Cardiovascular Ultrasound |
| Subjects: | |
| Online Access: | http://www.cardiovascularultrasound.com/content/10/1/32 |
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| author | Ishihara Yoshiyuki Kawasaki Masanori Hattori Arihiro Imai Hajime Takahashi Shigekiyo Sato Hironobu Kubota Tomoki Okubo Munenori Ojio Shinsuke Nishigaki Kazuhiko Takemura Genzou Fujiwara Hisayoshi Minatoguchi Shinya |
| author_facet | Ishihara Yoshiyuki Kawasaki Masanori Hattori Arihiro Imai Hajime Takahashi Shigekiyo Sato Hironobu Kubota Tomoki Okubo Munenori Ojio Shinsuke Nishigaki Kazuhiko Takemura Genzou Fujiwara Hisayoshi Minatoguchi Shinya |
| author_sort | Ishihara Yoshiyuki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to evaluate the mechanical properties of coronary plaques and plaque behavior, and to elucidate the relationship among tissue characteristics of coronary plaques, mechanical properties and coronary risk factors using integrated backscatter intravascular ultrasound (IB-IVUS).</p> <p>Methods</p> <p>Non-targeted plaques with moderate stenosis (plaque burden at the minimal lumen site: 50-70%) located proximal to the site of the percutaneous coronary intervention target lesions were evaluated by IB-IVUS. Thirty-six plaques (less calcified group: an arc of calcification ≤10°) in 36 patients and 22 plaques (moderately calcified group: 10° < an arc of calcification ≤60°) in 22 patients were evaluated. External elastic membrane volume (EEMV) compliance, lumen volume (LV) compliance, plaque volume (PV) response (difference between PV in systole and diastole), EEM area stiffness index were measured at the minimal lumen site. Relative lipid volume (lipid volume/internal elastic membrane volume) was calculated by IB-IVUS.</p> <p>Results</p> <p>In the less calcified group, there was a significant correlation between EEMV compliance and the relative lipid volume (r = 0.456, p = 0.005). There was a significant inverse correlation between EEM area stiffness index and the relative lipid volume (p = 0.032, r = −0.358). The LV compliance and EEM area stiffness index were significantly different in the diabetes mellitus (DM) group than in the non-DM group (1.32 ± 1.49 vs. 2.47 ± 1.79%/10 mmHg, p =0.014 and 28.3 ± 26.0 vs. 15.7 ± 17.2, p =0.020). The EEMV compliance and EEM area stiffness index were significantly different in the hypertension (HTN) group than in the non-HTN group (0.77 ± 0.68 vs. 1.57 ± 0.95%/10 mmHg, p =0.012 and 26.5 ± 24.3 vs. 13.0 ± 16.7, p =0.020). These relationships were not seen in the moderately calcified group.</p> <p>Conclusion</p> <p>The present study provided new findings that there was a significant correlation between mechanical properties and tissue characteristics of coronary arteries. In addition, our results suggested that the EEMV compliance and the LV compliance were independent and the compliance was significantly impaired in the patients with DM and/or HTN. Assessment of coronary mechanical properties during PCI may provide us with useful information regarding the risk stratification of patients with coronary heart disease.</p> |
| first_indexed | 2024-04-14T04:10:23Z |
| format | Article |
| id | doaj.art-29dab0cc2d044786b8d7662b3ef434f0 |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-04-14T04:10:23Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-29dab0cc2d044786b8d7662b3ef434f02022-12-22T02:13:13ZengBMCCardiovascular Ultrasound1476-71202012-07-011013210.1186/1476-7120-10-32Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasoundIshihara YoshiyukiKawasaki MasanoriHattori ArihiroImai HajimeTakahashi ShigekiyoSato HironobuKubota TomokiOkubo MunenoriOjio ShinsukeNishigaki KazuhikoTakemura GenzouFujiwara HisayoshiMinatoguchi Shinya<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to evaluate the mechanical properties of coronary plaques and plaque behavior, and to elucidate the relationship among tissue characteristics of coronary plaques, mechanical properties and coronary risk factors using integrated backscatter intravascular ultrasound (IB-IVUS).</p> <p>Methods</p> <p>Non-targeted plaques with moderate stenosis (plaque burden at the minimal lumen site: 50-70%) located proximal to the site of the percutaneous coronary intervention target lesions were evaluated by IB-IVUS. Thirty-six plaques (less calcified group: an arc of calcification ≤10°) in 36 patients and 22 plaques (moderately calcified group: 10° < an arc of calcification ≤60°) in 22 patients were evaluated. External elastic membrane volume (EEMV) compliance, lumen volume (LV) compliance, plaque volume (PV) response (difference between PV in systole and diastole), EEM area stiffness index were measured at the minimal lumen site. Relative lipid volume (lipid volume/internal elastic membrane volume) was calculated by IB-IVUS.</p> <p>Results</p> <p>In the less calcified group, there was a significant correlation between EEMV compliance and the relative lipid volume (r = 0.456, p = 0.005). There was a significant inverse correlation between EEM area stiffness index and the relative lipid volume (p = 0.032, r = −0.358). The LV compliance and EEM area stiffness index were significantly different in the diabetes mellitus (DM) group than in the non-DM group (1.32 ± 1.49 vs. 2.47 ± 1.79%/10 mmHg, p =0.014 and 28.3 ± 26.0 vs. 15.7 ± 17.2, p =0.020). The EEMV compliance and EEM area stiffness index were significantly different in the hypertension (HTN) group than in the non-HTN group (0.77 ± 0.68 vs. 1.57 ± 0.95%/10 mmHg, p =0.012 and 26.5 ± 24.3 vs. 13.0 ± 16.7, p =0.020). These relationships were not seen in the moderately calcified group.</p> <p>Conclusion</p> <p>The present study provided new findings that there was a significant correlation between mechanical properties and tissue characteristics of coronary arteries. In addition, our results suggested that the EEMV compliance and the LV compliance were independent and the compliance was significantly impaired in the patients with DM and/or HTN. Assessment of coronary mechanical properties during PCI may provide us with useful information regarding the risk stratification of patients with coronary heart disease.</p>http://www.cardiovascularultrasound.com/content/10/1/32Coronary artery diseaseIntravascular ultrasoundPlaqueStiffnessTissue |
| spellingShingle | Ishihara Yoshiyuki Kawasaki Masanori Hattori Arihiro Imai Hajime Takahashi Shigekiyo Sato Hironobu Kubota Tomoki Okubo Munenori Ojio Shinsuke Nishigaki Kazuhiko Takemura Genzou Fujiwara Hisayoshi Minatoguchi Shinya Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound Cardiovascular Ultrasound Coronary artery disease Intravascular ultrasound Plaque Stiffness Tissue |
| title | Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| title_full | Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| title_fullStr | Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| title_full_unstemmed | Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| title_short | Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| title_sort | relationship among coronary plaque compliance coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound |
| topic | Coronary artery disease Intravascular ultrasound Plaque Stiffness Tissue |
| url | http://www.cardiovascularultrasound.com/content/10/1/32 |
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