Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death

Abstract Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant cell growth and both processes represent targets for anticancer therapy. It is shown here that depletion of the AAA+‐ATPase thyroid hormone receptor interacting protein 13 (Trip13) results in mitoti...

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Bibliographic Details
Main Authors: Marcos Rios Garcia, Bettina Meissburger, Jessica Chan, Roldan M. deGuia, Frits Mattijssen, Stephanie Roessler, Andreas L. Birkenfeld, Nathanael Raschzok, Fabien Riols, Janina Tokarz, Maude Giroud, Manuel Gil Lozano, Goetz Hartleben, Peter Nawroth, Mark Haid, Miguel López, Stephan Herzig, Mauricio Berriel Diaz
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Advanced Science
Subjects:
hepatocellular carcinoma
lipogenesis
mitosis
MTOCs
Plin2
spindle assembly checkpoint
Online Access:https://doi.org/10.1002/advs.202104291

Internet

https://doi.org/10.1002/advs.202104291

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