Positron Emission Tomography in the Differential Diagnosis of Parkinsonism
Positron emission tomography (PET) studies on presynaptic dopaminergic function can reveal hypofunction in early Parkinson’s disease (PD) which may help in the early diagnosis especially in patients with mild symptoms. This hypofunction can be detected with fluorodopa (reflecting mainly aromatic ami...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Movement Disorder Society
2009-10-01
|
| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-2-2-53-1.pdf |
| _version_ | 1797760885726380032 |
|---|---|
| author | Juha O Rinne |
| author_facet | Juha O Rinne |
| author_sort | Juha O Rinne |
| collection | DOAJ |
| description | Positron emission tomography (PET) studies on presynaptic dopaminergic function can reveal hypofunction in early Parkinson’s disease (PD) which may help in the early diagnosis especially in patients with mild symptoms. This hypofunction can be detected with fluorodopa (reflecting mainly aromatic amino acid decarboxylase activity of nigrostriatal terminals) or dopamine transporter ligands. These studies can also help to distinguish PD from essential tremor. However, investigations of presynaptic dopaminergic function are not useful in the differential diagnosis of parkinsonian syndromes. PET ligands, such as fluorodeoxyglucose (reflecting glucose metabolism) and dopamine receptor ligands, reflecting striatal neuronal function are better in this respect. Cardiac sympathetic function studies represent a new and interesting approach to improve differential diagnosis of parkinsonian syndromes but more studies are needed in larger patient populations with longer follow-up to evaluate the usefulness of these investigations. Multitracer approach combining ligands reflecting different aspects of dopaminergic neurotransmission and other physiological function will increase differential diagnostic accuracy. |
| first_indexed | 2024-03-12T19:05:00Z |
| format | Article |
| id | doaj.art-29dcb258060341689fb0b445c43027f9 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T19:05:00Z |
| publishDate | 2009-10-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-29dcb258060341689fb0b445c43027f92023-08-02T06:17:00ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392009-10-0122535710.14802/jmd.0901569Positron Emission Tomography in the Differential Diagnosis of ParkinsonismJuha O RinnePositron emission tomography (PET) studies on presynaptic dopaminergic function can reveal hypofunction in early Parkinson’s disease (PD) which may help in the early diagnosis especially in patients with mild symptoms. This hypofunction can be detected with fluorodopa (reflecting mainly aromatic amino acid decarboxylase activity of nigrostriatal terminals) or dopamine transporter ligands. These studies can also help to distinguish PD from essential tremor. However, investigations of presynaptic dopaminergic function are not useful in the differential diagnosis of parkinsonian syndromes. PET ligands, such as fluorodeoxyglucose (reflecting glucose metabolism) and dopamine receptor ligands, reflecting striatal neuronal function are better in this respect. Cardiac sympathetic function studies represent a new and interesting approach to improve differential diagnosis of parkinsonian syndromes but more studies are needed in larger patient populations with longer follow-up to evaluate the usefulness of these investigations. Multitracer approach combining ligands reflecting different aspects of dopaminergic neurotransmission and other physiological function will increase differential diagnostic accuracy.http://e-jmd.org/upload/jmd-2-2-53-1.pdfParkinsonismPET |
| spellingShingle | Juha O Rinne Positron Emission Tomography in the Differential Diagnosis of Parkinsonism Journal of Movement Disorders Parkinsonism PET |
| title | Positron Emission Tomography in the Differential Diagnosis of Parkinsonism |
| title_full | Positron Emission Tomography in the Differential Diagnosis of Parkinsonism |
| title_fullStr | Positron Emission Tomography in the Differential Diagnosis of Parkinsonism |
| title_full_unstemmed | Positron Emission Tomography in the Differential Diagnosis of Parkinsonism |
| title_short | Positron Emission Tomography in the Differential Diagnosis of Parkinsonism |
| title_sort | positron emission tomography in the differential diagnosis of parkinsonism |
| topic | Parkinsonism PET |
| url | http://e-jmd.org/upload/jmd-2-2-53-1.pdf |
| work_keys_str_mv | AT juhaorinne positronemissiontomographyinthedifferentialdiagnosisofparkinsonism |