BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified the ubiquitously expressed tumour suppressor BRCA1-associated protein 1 (B...

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Bibliographic Details
Main Authors: Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
trophoblast
placenta
epithelial-mesenchymal transition
trophoblast invasion
stem cell self-renewal
CRISPR gene editing
Online Access:https://elifesciences.org/articles/63254

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