Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19
Background: Some patients with comorbidities and rapid disease progression have a poor prognosis.Aim: We aimed to investigate the characteristics of comorbidities and their relationship with disease progression and outcomes of COVID-19 patients.Methods: A total of 718 COVID-19 patients were divided...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.736109/full |
| _version_ | 1818974703327379456 |
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| author | Dafeng Liu Dafeng Liu Yongli Zheng Yongli Zheng Jun Kang Jun Kang Dongmei Wang Dongmei Wang Lang Bai Yi Mao Yi Mao Guifang Zha Guifang Zha Hong Tang Renqing Zhang Renqing Zhang |
| author_facet | Dafeng Liu Dafeng Liu Yongli Zheng Yongli Zheng Jun Kang Jun Kang Dongmei Wang Dongmei Wang Lang Bai Yi Mao Yi Mao Guifang Zha Guifang Zha Hong Tang Renqing Zhang Renqing Zhang |
| author_sort | Dafeng Liu |
| collection | DOAJ |
| description | Background: Some patients with comorbidities and rapid disease progression have a poor prognosis.Aim: We aimed to investigate the characteristics of comorbidities and their relationship with disease progression and outcomes of COVID-19 patients.Methods: A total of 718 COVID-19 patients were divided into five clinical type groups and eight age-interval groups. The characteristics of comorbidities were compared between the different clinical type groups and between the different age-interval groups, and their relationships with disease progression and outcomes of COVID-19 patients were assessed.Results: Approximately 91.23% (655/718) of COVID-19 patients were younger than 60 years old. Approximately 64.76% (465/718) had one or more comorbidities, and common comorbidities included non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes mellitus (DM), chronic hepatitis B (CHB), hyperuricaemia, and gout. COVID-19 patients with comorbidities were older, especially those with chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Hypertension, DM, COPD, chronic kidney disease (CKD) and CVD were mainly found in severe COVID-19 patients. According to spearman correlation analysis the number of comorbidities was correlated positively with disease severity, the number of comorbidities and NAFLD were correlated positively with virus negative conversion time, hypertension, CKD and CVD were primarily associated with those who died, and the above-mentioned correlation existed independently of age. Risk factors included age, the number of comorbidities and hyperlipidaemia for disease severity, the number of comorbidities, hyperlipidaemia, NAFLD and COPD for the virus negative conversion time, and the number of comorbidities and CKD for prognosis. Number of comorbidities and age played a predictive role in disease progression and outcomes.Conclusion: Not only high number and specific comorbidities but also age are closely related to progression and poor prognosis in patients with COVID-19. These findings provide a reference for clinicians to focus on not only the number and specific comorbidities but also age in COVID-19 patients to predict disease progression and prognosis.Clinical Trial Registry: Chinese Clinical Trial Register ChiCTR2000034563. |
| first_indexed | 2024-12-20T15:44:16Z |
| format | Article |
| id | doaj.art-29dfb64018d04f2989716db6ee6d273f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T15:44:16Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-29dfb64018d04f2989716db6ee6d273f2022-12-21T19:35:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.736109736109Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19Dafeng Liu0Dafeng Liu1Yongli Zheng2Yongli Zheng3Jun Kang4Jun Kang5Dongmei Wang6Dongmei Wang7Lang Bai8Yi Mao9Yi Mao10Guifang Zha11Guifang Zha12Hong Tang13Renqing Zhang14Renqing Zhang15Department of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaThe Public and Health Clinic Centre of Chengdu Substation, Chengdu New Emergent Infectious Disease Prevention and Control Workstation, Chengdu, ChinaBackground: Some patients with comorbidities and rapid disease progression have a poor prognosis.Aim: We aimed to investigate the characteristics of comorbidities and their relationship with disease progression and outcomes of COVID-19 patients.Methods: A total of 718 COVID-19 patients were divided into five clinical type groups and eight age-interval groups. The characteristics of comorbidities were compared between the different clinical type groups and between the different age-interval groups, and their relationships with disease progression and outcomes of COVID-19 patients were assessed.Results: Approximately 91.23% (655/718) of COVID-19 patients were younger than 60 years old. Approximately 64.76% (465/718) had one or more comorbidities, and common comorbidities included non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes mellitus (DM), chronic hepatitis B (CHB), hyperuricaemia, and gout. COVID-19 patients with comorbidities were older, especially those with chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Hypertension, DM, COPD, chronic kidney disease (CKD) and CVD were mainly found in severe COVID-19 patients. According to spearman correlation analysis the number of comorbidities was correlated positively with disease severity, the number of comorbidities and NAFLD were correlated positively with virus negative conversion time, hypertension, CKD and CVD were primarily associated with those who died, and the above-mentioned correlation existed independently of age. Risk factors included age, the number of comorbidities and hyperlipidaemia for disease severity, the number of comorbidities, hyperlipidaemia, NAFLD and COPD for the virus negative conversion time, and the number of comorbidities and CKD for prognosis. Number of comorbidities and age played a predictive role in disease progression and outcomes.Conclusion: Not only high number and specific comorbidities but also age are closely related to progression and poor prognosis in patients with COVID-19. These findings provide a reference for clinicians to focus on not only the number and specific comorbidities but also age in COVID-19 patients to predict disease progression and prognosis.Clinical Trial Registry: Chinese Clinical Trial Register ChiCTR2000034563.https://www.frontiersin.org/articles/10.3389/fmed.2021.736109/fullcoronavirus disease 2019 (COVID-19)comorbiditynumberprogressionprognosis |
| spellingShingle | Dafeng Liu Dafeng Liu Yongli Zheng Yongli Zheng Jun Kang Jun Kang Dongmei Wang Dongmei Wang Lang Bai Yi Mao Yi Mao Guifang Zha Guifang Zha Hong Tang Renqing Zhang Renqing Zhang Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 Frontiers in Medicine coronavirus disease 2019 (COVID-19) comorbidity number progression prognosis |
| title | Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 |
| title_full | Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 |
| title_fullStr | Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 |
| title_full_unstemmed | Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 |
| title_short | Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19 |
| title_sort | not only high number and specific comorbidities but also age are closely related to progression and poor prognosis in patients with covid 19 |
| topic | coronavirus disease 2019 (COVID-19) comorbidity number progression prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.736109/full |
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