Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome
Noonan syndrome (NS) is a dominant clinically variable and genetically heterogeneous developmental disorder caused by germ-line mutations encoding components of the Ras–MAPK signaling pathway. A few studies have investigated psychopathological features occurring in individuals with NS, although they...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/233 |
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| author | Paolo Alfieri Francesca Cumbo Giulia Serra Monia Trasolini Camilla Frattini Francesco Scibelli Serena Licchelli Flavia Cirillo Cristina Caciolo Maria Pia Casini Adele D’Amico Marco Tartaglia Maria Cristina Digilio Rossella Capolino Stefano Vicari |
| author_facet | Paolo Alfieri Francesca Cumbo Giulia Serra Monia Trasolini Camilla Frattini Francesco Scibelli Serena Licchelli Flavia Cirillo Cristina Caciolo Maria Pia Casini Adele D’Amico Marco Tartaglia Maria Cristina Digilio Rossella Capolino Stefano Vicari |
| author_sort | Paolo Alfieri |
| collection | DOAJ |
| description | Noonan syndrome (NS) is a dominant clinically variable and genetically heterogeneous developmental disorder caused by germ-line mutations encoding components of the Ras–MAPK signaling pathway. A few studies have investigated psychopathological features occurring in individuals with NS, although they were poorly analyzed. The aim of the present work is to investigate the psychopathological features in children and adolescents with NS focusing on depressive and hypo-manic symptoms. Thirty-seven subjects with molecularly confirmed diagnosis were systematically evaluated through a psychopathological assessment. In addition, an evaluation of the cognitive level was performed. Our analyses showed a high recurrence of attention deficit and hyperactivity disorder symptoms, emotional dysregulation, irritability, and anxiety symptomatology. The mean cognitive level was on the average. The present study provides new relevant information on psychopathological features in individuals with NS. The implications for clinicians are discussed including the monitoring of mood disorders in a clinical evolution. |
| first_indexed | 2024-03-09T00:55:18Z |
| format | Article |
| id | doaj.art-29dfd9051c164f5f831e577089260789 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T00:55:18Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-29dfd9051c164f5f831e5770892607892023-12-11T16:56:28ZengMDPI AGBrain Sciences2076-34252021-02-0111223310.3390/brainsci11020233Manic and Depressive Symptoms in Children Diagnosed with Noonan SyndromePaolo Alfieri0Francesca Cumbo1Giulia Serra2Monia Trasolini3Camilla Frattini4Francesco Scibelli5Serena Licchelli6Flavia Cirillo7Cristina Caciolo8Maria Pia Casini9Adele D’Amico10Marco Tartaglia11Maria Cristina Digilio12Rossella Capolino13Stefano Vicari14Child and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyGenetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyGenetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyGenetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyChild and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNoonan syndrome (NS) is a dominant clinically variable and genetically heterogeneous developmental disorder caused by germ-line mutations encoding components of the Ras–MAPK signaling pathway. A few studies have investigated psychopathological features occurring in individuals with NS, although they were poorly analyzed. The aim of the present work is to investigate the psychopathological features in children and adolescents with NS focusing on depressive and hypo-manic symptoms. Thirty-seven subjects with molecularly confirmed diagnosis were systematically evaluated through a psychopathological assessment. In addition, an evaluation of the cognitive level was performed. Our analyses showed a high recurrence of attention deficit and hyperactivity disorder symptoms, emotional dysregulation, irritability, and anxiety symptomatology. The mean cognitive level was on the average. The present study provides new relevant information on psychopathological features in individuals with NS. The implications for clinicians are discussed including the monitoring of mood disorders in a clinical evolution.https://www.mdpi.com/2076-3425/11/2/233psychopathological featuresattention deficit and hyperactivity disorderdeficient emotional self-regulationirritabilityanxiety traitsmood |
| spellingShingle | Paolo Alfieri Francesca Cumbo Giulia Serra Monia Trasolini Camilla Frattini Francesco Scibelli Serena Licchelli Flavia Cirillo Cristina Caciolo Maria Pia Casini Adele D’Amico Marco Tartaglia Maria Cristina Digilio Rossella Capolino Stefano Vicari Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome Brain Sciences psychopathological features attention deficit and hyperactivity disorder deficient emotional self-regulation irritability anxiety traits mood |
| title | Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome |
| title_full | Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome |
| title_fullStr | Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome |
| title_full_unstemmed | Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome |
| title_short | Manic and Depressive Symptoms in Children Diagnosed with Noonan Syndrome |
| title_sort | manic and depressive symptoms in children diagnosed with noonan syndrome |
| topic | psychopathological features attention deficit and hyperactivity disorder deficient emotional self-regulation irritability anxiety traits mood |
| url | https://www.mdpi.com/2076-3425/11/2/233 |
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