Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer worldwide. A diagnosis at early stages with enhanced screening methods is vital as metastases and recurrences increase mortality. The aim of this study was to analyze the tumor markers CEA and CA19-9 combined in correlation with diagnostics and...
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MDPI AG
2021-03-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/9/1/21 |
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| author | Leilani Lakemeyer Silvia Sander Mathias Wittau Doris Henne-Bruns Marko Kornmann Johannes Lemke |
| author_facet | Leilani Lakemeyer Silvia Sander Mathias Wittau Doris Henne-Bruns Marko Kornmann Johannes Lemke |
| author_sort | Leilani Lakemeyer |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common cancer worldwide. A diagnosis at early stages with enhanced screening methods is vital as metastases and recurrences increase mortality. The aim of this study was to analyze the tumor markers CEA and CA19-9 combined in correlation with diagnostics and prognosis. Therefore, 1487 patients with CRC who were diagnosed and treated between 2000 and 2015 at the University Hospital Ulm, Germany, were retrospectively evaluated. Overall and recurrence-free survival was analyzed in association with preoperative CEA and CA19-9 separately and combined and a multivariate analysis was performed. The 5-year overall survival was significantly shorter in patients with a CEA or CA19-9 level ≥200 compared to patients with an increased, but <200, or normal level (CEA: 69%/44%/7%; CA19-9: 66%/38%/8%). Patients with both tumor markers increased also showed a remarkably shorter 5-year survival rate (CEA+/CA19-9+: 23%). The multivariate analysis emphasizes these results (<i>p</i>-value < 0.0001). Patients with both tumor markers elevated had the shortest 5-year recurrence-free survival rate, followed by patients with either CEA or CA19-9 elevated (CEA-/CA19-9-: 79%; CEA+/CA19-9; CEA-/CA19-9+: 65%; CEA+/CA19-9+: 44%). In conclusion, measuring CEA and CA19-9 preoperatively in CRC patients is reasonable and could be useful as a prognostic factor. |
| first_indexed | 2024-03-10T13:08:29Z |
| format | Article |
| id | doaj.art-29e043ff93b74b47ba0df8764da277aa |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T13:08:29Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-29e043ff93b74b47ba0df8764da277aa2023-11-21T10:54:31ZengMDPI AGDiseases2079-97212021-03-01912110.3390/diseases9010021Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal CancerLeilani Lakemeyer0Silvia Sander1Mathias Wittau2Doris Henne-Bruns3Marko Kornmann4Johannes Lemke5Department of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, GermanyInstitute of Epidemiology and Medical Biometry, University of Ulm, 89081 Ulm, GermanyDepartment of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, GermanyDepartment of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, GermanyDepartment of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, GermanyDepartment of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, GermanyColorectal cancer (CRC) is the third most common cancer worldwide. A diagnosis at early stages with enhanced screening methods is vital as metastases and recurrences increase mortality. The aim of this study was to analyze the tumor markers CEA and CA19-9 combined in correlation with diagnostics and prognosis. Therefore, 1487 patients with CRC who were diagnosed and treated between 2000 and 2015 at the University Hospital Ulm, Germany, were retrospectively evaluated. Overall and recurrence-free survival was analyzed in association with preoperative CEA and CA19-9 separately and combined and a multivariate analysis was performed. The 5-year overall survival was significantly shorter in patients with a CEA or CA19-9 level ≥200 compared to patients with an increased, but <200, or normal level (CEA: 69%/44%/7%; CA19-9: 66%/38%/8%). Patients with both tumor markers increased also showed a remarkably shorter 5-year survival rate (CEA+/CA19-9+: 23%). The multivariate analysis emphasizes these results (<i>p</i>-value < 0.0001). Patients with both tumor markers elevated had the shortest 5-year recurrence-free survival rate, followed by patients with either CEA or CA19-9 elevated (CEA-/CA19-9-: 79%; CEA+/CA19-9; CEA-/CA19-9+: 65%; CEA+/CA19-9+: 44%). In conclusion, measuring CEA and CA19-9 preoperatively in CRC patients is reasonable and could be useful as a prognostic factor.https://www.mdpi.com/2079-9721/9/1/21colorectal cancerCEACA19-9carcinoembryonic antigencarbohydrate antigen 19-9biomarkers |
| spellingShingle | Leilani Lakemeyer Silvia Sander Mathias Wittau Doris Henne-Bruns Marko Kornmann Johannes Lemke Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer Diseases colorectal cancer CEA CA19-9 carcinoembryonic antigen carbohydrate antigen 19-9 biomarkers |
| title | Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer |
| title_full | Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer |
| title_fullStr | Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer |
| title_full_unstemmed | Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer |
| title_short | Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer |
| title_sort | diagnostic and prognostic value of cea and ca19 9 in colorectal cancer |
| topic | colorectal cancer CEA CA19-9 carcinoembryonic antigen carbohydrate antigen 19-9 biomarkers |
| url | https://www.mdpi.com/2079-9721/9/1/21 |
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