CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY
The aim of research – the study of cardioprotective properties of antioxidants in terms of histotoxic hypoxia under experimental conditions.Materials and methods. The study was conducted on 20 adult male Wistar rats divided into 3 experimental groups, which for 7 days were intraperitoneally injected...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2016-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/598 |
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| author | I. V. Zadnipryany O. S. Tretiakova A. V. Kubyshkin T. P. Sataieva |
| author_facet | I. V. Zadnipryany O. S. Tretiakova A. V. Kubyshkin T. P. Sataieva |
| author_sort | I. V. Zadnipryany |
| collection | DOAJ |
| description | The aim of research – the study of cardioprotective properties of antioxidants in terms of histotoxic hypoxia under experimental conditions.Materials and methods. The study was conducted on 20 adult male Wistar rats divided into 3 experimental groups, which for 7 days were intraperitoneally injected aqueous CoCl2 solution at a dose of 60 mg/kg. Rats of the first experimental group (n = 6) had no administered drug correction, a the second group of animals (n = 7) after the cobalt chloride daily injections was administered intragastrically Enoant Premium aqueous solution at a dose of 2.5 ml / kg, along with 0.05 ml of water, the rats the third test group (n = 7) after the administration of cobalt chloride were exposed to cytoflavin correction concentrate and grape polyphenols administered simultaneously. Studies of myocardium were conducted using light and electron microscopy.Results of the research. The result of the cobalt toxic effect on the heart of animals in experiments lead to the development of cardiomyopathy, which required timely cardioprotection. Morphological changes in the second group of rats, despite a slight improvement compared with the group without correction,were characterized, above all, by uneven from mild to severe edema of the myocardium. Structure of myocardium observed in the third group of male rats after cobalt intoxication, generally reflected a tendency to minimization of the extent of the damage, which was manifested in the form of normalization of cell structures and muscle fibers.Conclusion. The administration of succinic acid derivatives combined with the grape polyphenols demonstrated vivid cytoprotective properties evidenced by mostly preserved myocardium structure in rats exposed to histotoxic hypoxia in comparison to only administration of plant polyphenols group. |
| first_indexed | 2024-04-10T01:07:14Z |
| format | Article |
| id | doaj.art-29e0ae25a2584890aa3a4b2112ce7210 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:14Z |
| publishDate | 2016-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-29e0ae25a2584890aa3a4b2112ce72102023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-06-01153334010.20538/1682-0363-2016-3-33-40543CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHYI. V. Zadnipryany0O. S. Tretiakova1A. V. Kubyshkin2T. P. Sataieva3Медицинская академия имени С.И. Георгиевского ФГАОУ ВО «КФУ им. В.И. Вернадского», г. СимферопольМедицинская академия имени С.И. Георгиевского ФГАОУ ВО «КФУ им. В.И. Вернадского», г. СимферопольМедицинская академия имени С.И. Георгиевского ФГАОУ ВО «КФУ им. В.И. Вернадского», г. СимферопольМедицинская академия имени С.И. Георгиевского ФГАОУ ВО «КФУ им. В.И. Вернадского», г. СимферопольThe aim of research – the study of cardioprotective properties of antioxidants in terms of histotoxic hypoxia under experimental conditions.Materials and methods. The study was conducted on 20 adult male Wistar rats divided into 3 experimental groups, which for 7 days were intraperitoneally injected aqueous CoCl2 solution at a dose of 60 mg/kg. Rats of the first experimental group (n = 6) had no administered drug correction, a the second group of animals (n = 7) after the cobalt chloride daily injections was administered intragastrically Enoant Premium aqueous solution at a dose of 2.5 ml / kg, along with 0.05 ml of water, the rats the third test group (n = 7) after the administration of cobalt chloride were exposed to cytoflavin correction concentrate and grape polyphenols administered simultaneously. Studies of myocardium were conducted using light and electron microscopy.Results of the research. The result of the cobalt toxic effect on the heart of animals in experiments lead to the development of cardiomyopathy, which required timely cardioprotection. Morphological changes in the second group of rats, despite a slight improvement compared with the group without correction,were characterized, above all, by uneven from mild to severe edema of the myocardium. Structure of myocardium observed in the third group of male rats after cobalt intoxication, generally reflected a tendency to minimization of the extent of the damage, which was manifested in the form of normalization of cell structures and muscle fibers.Conclusion. The administration of succinic acid derivatives combined with the grape polyphenols demonstrated vivid cytoprotective properties evidenced by mostly preserved myocardium structure in rats exposed to histotoxic hypoxia in comparison to only administration of plant polyphenols group.https://bulletin.ssmu.ru/jour/article/view/598миокардгипоксияантигипоксантыкобальткрысыэксперимент |
| spellingShingle | I. V. Zadnipryany O. S. Tretiakova A. V. Kubyshkin T. P. Sataieva CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY Бюллетень сибирской медицины миокард гипоксия антигипоксанты кобальт крысы эксперимент |
| title | CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY |
| title_full | CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY |
| title_fullStr | CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY |
| title_full_unstemmed | CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY |
| title_short | CARDIOPROTECTIVE EFFECT OF NATIVE ANTIHYPOXANTS IN EXPERIMENTAL COBALT CARDIOMYOPATHY |
| title_sort | cardioprotective effect of native antihypoxants in experimental cobalt cardiomyopathy |
| topic | миокард гипоксия антигипоксанты кобальт крысы эксперимент |
| url | https://bulletin.ssmu.ru/jour/article/view/598 |
| work_keys_str_mv | AT ivzadnipryany cardioprotectiveeffectofnativeantihypoxantsinexperimentalcobaltcardiomyopathy AT ostretiakova cardioprotectiveeffectofnativeantihypoxantsinexperimentalcobaltcardiomyopathy AT avkubyshkin cardioprotectiveeffectofnativeantihypoxantsinexperimentalcobaltcardiomyopathy AT tpsataieva cardioprotectiveeffectofnativeantihypoxantsinexperimentalcobaltcardiomyopathy |