Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
AimThere is insufficient evidence regarding the efficacy and safety of stem cell therapy for autism spectrum disorders. We performed the first meta-analysis of stem cell therapy for autism spectrum disorders in children to provide evidence for clinical rehabilitation.MethodsThe data source includes...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.897398/full |
| _version_ | 1828399680602505216 |
|---|---|
| author | Jiayang Qu Jiayang Qu Jiayang Qu Zicai Liu Lincai Li Lincai Li Zhengwei Zou Zhengwei Zou Zhengyi He Zhengyi He Zhengyi He Lin Zhou Lin Zhou Yaolin Luo Yaolin Luo Yaolin Luo Minhong Zhang Minhong Zhang Minhong Zhang Junsong Ye Junsong Ye Junsong Ye Junsong Ye Junsong Ye |
| author_facet | Jiayang Qu Jiayang Qu Jiayang Qu Zicai Liu Lincai Li Lincai Li Zhengwei Zou Zhengwei Zou Zhengyi He Zhengyi He Zhengyi He Lin Zhou Lin Zhou Yaolin Luo Yaolin Luo Yaolin Luo Minhong Zhang Minhong Zhang Minhong Zhang Junsong Ye Junsong Ye Junsong Ye Junsong Ye Junsong Ye |
| author_sort | Jiayang Qu |
| collection | DOAJ |
| description | AimThere is insufficient evidence regarding the efficacy and safety of stem cell therapy for autism spectrum disorders. We performed the first meta-analysis of stem cell therapy for autism spectrum disorders in children to provide evidence for clinical rehabilitation.MethodsThe data source includes PubMed/Medline, Web of Science, EMBASE, Cochrane Library and China Academic Journal, from inception to 24th JULY 2021. After sifting through the literature, the Cochrane tool was applied to assess the risk of bias. Finally, we extracted data from these studies and calculated pooled efficacy and safety.Results5 studies that met the inclusion criteria were included in current analysis. Meta-analysis was performed using rehabilitation therapy as the reference standard. Data showed that the Childhood Autism Rating Scale score of stem cell group was striking lower than the control group (WMD: −5.96; 95%CI [−8.87, −3.06]; p < 0.0001). The Clinical Global Impression score consolidated effect size RR = 1.01, 95%CI [0.87, 1.18], Z = 0.14 (p = 0.89), the effective rate for The Clinical Global Impression was 62% and 60% in the stem cell group and the control group, respectively. The occurrence events of adverse reactions in each group (RR = 1.55; 95%CI = 0.60 to 3.98; p = 0.36), there was no significant difference in the incidence of adverse reactions between the stem cell group and the control group.ConclusionsThe results of this meta-analysis suggested that stem cell therapy for children with autism might be safe and effective. However, the evidence was compromised by the limitations in current study size, lacking standardized injection routes and doses of stem cells, as well as shortages in diagnostic tools and long period follow-up studies. Hence, it calls for more studies to systematically confirm the efficacy and safety of stem cell therapy for children with autism spectrum disorders. |
| first_indexed | 2024-12-10T09:21:00Z |
| format | Article |
| id | doaj.art-29e14b432869495fa8b3a61f2a861524 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T09:21:00Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-29e14b432869495fa8b3a61f2a8615242022-12-22T01:54:42ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-05-011010.3389/fped.2022.897398897398Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-AnalysisJiayang Qu0Jiayang Qu1Jiayang Qu2Zicai Liu3Lincai Li4Lincai Li5Zhengwei Zou6Zhengwei Zou7Zhengyi He8Zhengyi He9Zhengyi He10Lin Zhou11Lin Zhou12Yaolin Luo13Yaolin Luo14Yaolin Luo15Minhong Zhang16Minhong Zhang17Minhong Zhang18Junsong Ye19Junsong Ye20Junsong Ye21Junsong Ye22Junsong Ye23The First Clinical Medicine College of Gannan Medical University, Ganzhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaSchool of Rehabilitation Medicine Gannan Medical University, GanZhou, ChinaSchool of Rehabilitation Medicine Gannan Medical University, GanZhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaClinical Medicine Research Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaClinical Medicine Research Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaClinical Medicine Research Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical Medicine College of Gannan Medical University, Ganzhou, ChinaSubcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Stem Cell and Regenerative Medicine, GanZhou, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaKey Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Gannan Medical University, Ganzhou, ChinaAimThere is insufficient evidence regarding the efficacy and safety of stem cell therapy for autism spectrum disorders. We performed the first meta-analysis of stem cell therapy for autism spectrum disorders in children to provide evidence for clinical rehabilitation.MethodsThe data source includes PubMed/Medline, Web of Science, EMBASE, Cochrane Library and China Academic Journal, from inception to 24th JULY 2021. After sifting through the literature, the Cochrane tool was applied to assess the risk of bias. Finally, we extracted data from these studies and calculated pooled efficacy and safety.Results5 studies that met the inclusion criteria were included in current analysis. Meta-analysis was performed using rehabilitation therapy as the reference standard. Data showed that the Childhood Autism Rating Scale score of stem cell group was striking lower than the control group (WMD: −5.96; 95%CI [−8.87, −3.06]; p < 0.0001). The Clinical Global Impression score consolidated effect size RR = 1.01, 95%CI [0.87, 1.18], Z = 0.14 (p = 0.89), the effective rate for The Clinical Global Impression was 62% and 60% in the stem cell group and the control group, respectively. The occurrence events of adverse reactions in each group (RR = 1.55; 95%CI = 0.60 to 3.98; p = 0.36), there was no significant difference in the incidence of adverse reactions between the stem cell group and the control group.ConclusionsThe results of this meta-analysis suggested that stem cell therapy for children with autism might be safe and effective. However, the evidence was compromised by the limitations in current study size, lacking standardized injection routes and doses of stem cells, as well as shortages in diagnostic tools and long period follow-up studies. Hence, it calls for more studies to systematically confirm the efficacy and safety of stem cell therapy for children with autism spectrum disorders.https://www.frontiersin.org/articles/10.3389/fped.2022.897398/fullautism spectrum disorders (ASD)stem cell therapymeta-analysisefficacysafety |
| spellingShingle | Jiayang Qu Jiayang Qu Jiayang Qu Zicai Liu Lincai Li Lincai Li Zhengwei Zou Zhengwei Zou Zhengyi He Zhengyi He Zhengyi He Lin Zhou Lin Zhou Yaolin Luo Yaolin Luo Yaolin Luo Minhong Zhang Minhong Zhang Minhong Zhang Junsong Ye Junsong Ye Junsong Ye Junsong Ye Junsong Ye Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis Frontiers in Pediatrics autism spectrum disorders (ASD) stem cell therapy meta-analysis efficacy safety |
| title | Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| title_full | Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| title_short | Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis |
| title_sort | efficacy and safety of stem cell therapy in children with autism spectrum disorders a systematic review and meta analysis |
| topic | autism spectrum disorders (ASD) stem cell therapy meta-analysis efficacy safety |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.897398/full |
| work_keys_str_mv | AT jiayangqu efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT jiayangqu efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT jiayangqu efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zicailiu efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT lincaili efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT lincaili efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zhengweizou efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zhengweizou efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zhengyihe efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zhengyihe efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT zhengyihe efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT linzhou efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT linzhou efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT yaolinluo efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT yaolinluo efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT yaolinluo efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT minhongzhang efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT minhongzhang efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT minhongzhang efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT junsongye efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT junsongye efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT junsongye efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT junsongye efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis AT junsongye efficacyandsafetyofstemcelltherapyinchildrenwithautismspectrumdisordersasystematicreviewandmetaanalysis |