Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid
Abstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12136 |
| _version_ | 1797975503981772800 |
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| author | Yen Ying Lim Jenalle E. Baker Andrea Mills Loren Bruns Jr Christopher Fowler Jurgen Fripp Stephanie R. Rainey‐Smith David Ames Colin L Masters Paul Maruff |
| author_facet | Yen Ying Lim Jenalle E. Baker Andrea Mills Loren Bruns Jr Christopher Fowler Jurgen Fripp Stephanie R. Rainey‐Smith David Ames Colin L Masters Paul Maruff |
| author_sort | Yen Ying Lim |
| collection | DOAJ |
| description | Abstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT) over 6 days. Results Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non‐carriers (d = 0.3). Rates of learning on the ORCA‐LLT were significantly slower in Aβ– ε4 carriers compared to non‐carriers (d = 1.2). Discussion In Aβ– CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA‐LLT. Alzheimer's disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds. |
| first_indexed | 2024-04-11T04:36:36Z |
| format | Article |
| id | doaj.art-29e1c02bde994115af43b8750883003a |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:36:36Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-29e1c02bde994115af43b8750883003a2022-12-28T09:12:14ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12136Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloidYen Ying Lim0Jenalle E. Baker1Andrea Mills2Loren Bruns Jr3Christopher Fowler4Jurgen Fripp5Stephanie R. Rainey‐Smith6David Ames7Colin L Masters8Paul Maruff9Turner Institute for Brain and Mental Health, School of Psychological Sciences Monash University Clayton Victoria AustraliaThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria AustraliaTurner Institute for Brain and Mental Health, School of Psychological Sciences Monash University Clayton Victoria AustraliaSchool of Computing and Information Systems University of Melbourne Parkville Victoria AustraliaThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria AustraliaCSIRO Health and Biosecurity Australian e‐Health Research Centre Brisbane Queensland AustraliaCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences Edith Cowan University Perth Western Australia AustraliaNational Ageing Research Institute Parkville Victoria AustraliaThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria AustraliaThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria AustraliaAbstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT) over 6 days. Results Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non‐carriers (d = 0.3). Rates of learning on the ORCA‐LLT were significantly slower in Aβ– ε4 carriers compared to non‐carriers (d = 1.2). Discussion In Aβ– CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA‐LLT. Alzheimer's disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds.https://doi.org/10.1002/dad2.12136Alzheimer's diseaseamyloidapolipoprotein Elearningmemory |
| spellingShingle | Yen Ying Lim Jenalle E. Baker Andrea Mills Loren Bruns Jr Christopher Fowler Jurgen Fripp Stephanie R. Rainey‐Smith David Ames Colin L Masters Paul Maruff Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease amyloid apolipoprotein E learning memory |
| title | Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
| title_full | Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
| title_fullStr | Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
| title_full_unstemmed | Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
| title_short | Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
| title_sort | learning deficit in cognitively normal apoe ε4 carriers with low β amyloid |
| topic | Alzheimer's disease amyloid apolipoprotein E learning memory |
| url | https://doi.org/10.1002/dad2.12136 |
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