Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice
Purpose: to identify statistically significant factors that determine adherence to long-term follow-up on the part of patients receiving anti-VEGF therapy for macular diseases.Material and methods. A retrospective analysis was performed on 247 patients (153 women, 94 men) aged 24 to 92 years treated...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2021-03-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/575 |
| _version_ | 1797878274593914880 |
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| author | E. V. Bobykin V. Y. Krokhalev R. V. Buslaev O. V. Morozova |
| author_facet | E. V. Bobykin V. Y. Krokhalev R. V. Buslaev O. V. Morozova |
| author_sort | E. V. Bobykin |
| collection | DOAJ |
| description | Purpose: to identify statistically significant factors that determine adherence to long-term follow-up on the part of patients receiving anti-VEGF therapy for macular diseases.Material and methods. A retrospective analysis was performed on 247 patients (153 women, 94 men) aged 24 to 92 years treated with anti-VEGF for “wet” age-related macular degeneration (n = 164), diabetic macular edema (n = 18), macular edema due to retinal vein occlusion (n = 35) and myopic choroidal neovascularization (n = 30). Demographic data and treatment results were statistically analyzed with the STATISTICA 13.3 program (normal conditions for variables, non-parametric and parametric criteria were determined).Results. Follow-up duration was shown to depend on gender (women are more committed to long-term treatment, p < 0.05), diagnosis (the longest follow-up related to myopic choroidal neovascularization patients), initial and final visual acuity. The comparison of subgroups of patients with the longest (over 30 months, n = 56) and shortest (till 12 months, n = 92) follow-up showed that prolonged monitoring corresponds to higher values of the initial (p < 0.01) and final (p < 0.05) visual acuity, as well as a lower average number of injections over the entire follow-up (p < 0.001) and a younger age of patients (p = 0.02).Conclusion. The follow-up duration depends on gender and age, the intensity of treatment, as well as on the initial and final visual acuity at a significance level of ˂ 0.05. Also, the follow-up duration depends on the particular diagnosis. An indicator clearly reflecting the severity of the burden of treatment is proposed: the coefficient of therapy intensity which is inversely related to the patient’s adherence to therapy. |
| first_indexed | 2024-04-10T02:30:05Z |
| format | Article |
| id | doaj.art-29e1c13d70e14e54b31ae438d4a2cd44 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:30:05Z |
| publishDate | 2021-03-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-29e1c13d70e14e54b31ae438d4a2cd442023-03-13T07:54:31ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602021-03-01141212910.21516/2072-0076-2021-14-1-21-29328Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practiceE. V. Bobykin0V. Y. Krokhalev1R. V. Buslaev2O. V. Morozova3ФГБОУ ВО Уральский государственный медицинский университет Минздрава РоссииФГБОУ ВО Уральский государственный медицинский университет Минздрава РоссииФГБОУ ВО Уральский государственный медицинский университет Минздрава РоссииФГБОУ ВО Уральский государственный медицинский университет Минздрава РоссииPurpose: to identify statistically significant factors that determine adherence to long-term follow-up on the part of patients receiving anti-VEGF therapy for macular diseases.Material and methods. A retrospective analysis was performed on 247 patients (153 women, 94 men) aged 24 to 92 years treated with anti-VEGF for “wet” age-related macular degeneration (n = 164), diabetic macular edema (n = 18), macular edema due to retinal vein occlusion (n = 35) and myopic choroidal neovascularization (n = 30). Demographic data and treatment results were statistically analyzed with the STATISTICA 13.3 program (normal conditions for variables, non-parametric and parametric criteria were determined).Results. Follow-up duration was shown to depend on gender (women are more committed to long-term treatment, p < 0.05), diagnosis (the longest follow-up related to myopic choroidal neovascularization patients), initial and final visual acuity. The comparison of subgroups of patients with the longest (over 30 months, n = 56) and shortest (till 12 months, n = 92) follow-up showed that prolonged monitoring corresponds to higher values of the initial (p < 0.01) and final (p < 0.05) visual acuity, as well as a lower average number of injections over the entire follow-up (p < 0.001) and a younger age of patients (p = 0.02).Conclusion. The follow-up duration depends on gender and age, the intensity of treatment, as well as on the initial and final visual acuity at a significance level of ˂ 0.05. Also, the follow-up duration depends on the particular diagnosis. An indicator clearly reflecting the severity of the burden of treatment is proposed: the coefficient of therapy intensity which is inversely related to the patient’s adherence to therapy.https://roj.igb.ru/jour/article/view/575продолжительность наблюденияантиангиогенная терапиязаболевания макулыстатистический анализ |
| spellingShingle | E. V. Bobykin V. Y. Krokhalev R. V. Buslaev O. V. Morozova Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice Российский офтальмологический журнал продолжительность наблюдения антиангиогенная терапия заболевания макулы статистический анализ |
| title | Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice |
| title_full | Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice |
| title_fullStr | Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice |
| title_full_unstemmed | Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice |
| title_short | Factors determining the compliance of patients receiving anti-VEGF therapy for macular diseases with long-term follow-up in real-life practice |
| title_sort | factors determining the compliance of patients receiving anti vegf therapy for macular diseases with long term follow up in real life practice |
| topic | продолжительность наблюдения антиангиогенная терапия заболевания макулы статистический анализ |
| url | https://roj.igb.ru/jour/article/view/575 |
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