Fructose: Toxic effect on cardiorenal risk factors and redox state
Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F g...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-12-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/2050312116684294 |
| _version_ | 1818990321785110528 |
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| author | Fabiane V Francisqueti Klinsmann C Santos Artur JT Ferron Angelo TC Lo Igor O Minatel Dijon HS Campos Ana Lucia A Ferreira Camila R Corrêa |
| author_facet | Fabiane V Francisqueti Klinsmann C Santos Artur JT Ferron Angelo TC Lo Igor O Minatel Dijon HS Campos Ana Lucia A Ferreira Camila R Corrêa |
| author_sort | Fabiane V Francisqueti |
| collection | DOAJ |
| description | Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure. |
| first_indexed | 2024-12-20T19:52:31Z |
| format | Article |
| id | doaj.art-29e3109a14334a9c8085743f4804ec48 |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-20T19:52:31Z |
| publishDate | 2016-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-29e3109a14334a9c8085743f4804ec482022-12-21T19:28:16ZengSAGE PublishingSAGE Open Medicine2050-31212016-12-01410.1177/205031211668429410.1177_2050312116684294Fructose: Toxic effect on cardiorenal risk factors and redox stateFabiane V Francisqueti0Klinsmann C Santos1Artur JT Ferron2Angelo TC Lo3Igor O Minatel4Dijon HS Campos5Ana Lucia A Ferreira6Camila R Corrêa7State University (Unesp), Medical School, BotucatuState University (Unesp), Medical School, BotucatuState University (Unesp), Medical School, BotucatuState University (Unesp), Medical School, BotucatuState University (Unesp), Institute of Biosciences, BotucatuState University (Unesp), Medical School, BotucatuState University (Unesp), Medical School, BotucatuState University (Unesp), Medical School, BotucatuAim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.https://doi.org/10.1177/2050312116684294 |
| spellingShingle | Fabiane V Francisqueti Klinsmann C Santos Artur JT Ferron Angelo TC Lo Igor O Minatel Dijon HS Campos Ana Lucia A Ferreira Camila R Corrêa Fructose: Toxic effect on cardiorenal risk factors and redox state SAGE Open Medicine |
| title | Fructose: Toxic effect on cardiorenal risk factors and redox state |
| title_full | Fructose: Toxic effect on cardiorenal risk factors and redox state |
| title_fullStr | Fructose: Toxic effect on cardiorenal risk factors and redox state |
| title_full_unstemmed | Fructose: Toxic effect on cardiorenal risk factors and redox state |
| title_short | Fructose: Toxic effect on cardiorenal risk factors and redox state |
| title_sort | fructose toxic effect on cardiorenal risk factors and redox state |
| url | https://doi.org/10.1177/2050312116684294 |
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