LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

Abstract It has become evident that Alzheimer’s Disease (AD) is not only linked to its hallmark lesions—amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring pathologies. This may lead to synergistic effects of the respective cellular and molecular players, resulting in n...

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Bibliographic Details
Main Authors: Marta J. Koper, Sandra O. Tomé, Klara Gawor, Annelies Belet, Evelien Van Schoor, Jolien Schaeverbeke, Rik Vandenberghe, Mathieu Vandenbulcke, Estifanos Ghebremedhin, Markus Otto, Christine A. F. von Arnim, Sriram Balusu, Matthew B. Blaschko, Bart De Strooper, Dietmar Rudolf Thal
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Granulovacuolar degeneration
LATE-NC
TDP-43
Necroptosis
Cell death
pMLKL
Online Access:https://doi.org/10.1186/s40478-022-01432-6

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