Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

Abstract Background Anti-CD19 CAR T cell therapy has demonstrated high response rates in patients with relapsed or refractory (r/r) B cell malignancies but is associated with significant toxicity. Cytokine release syndrome (CRS) is the most significant complication associated with CAR T cell therapy...

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Bibliographic Details
Main Authors: David Porter, Noelle Frey, Patricia A. Wood, Yanqiu Weng, Stephan A. Grupp
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Hematology & Oncology
Subjects:
CAR T cell therapy
Cytokine release syndrome
Safety
Online Access:http://link.springer.com/article/10.1186/s13045-018-0571-y

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