Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study
Previous evidence associates insulin resistance with arterial stiffness in various pathologies, yet limited reports exist in healthy adults. Therefore, this study aims to estimate the association between insulin resistance and arterial stiffness in healthy adults. The cross-sectional EVasCu study en...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/6/791 |
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| author | Carlos Pascual-Morena Iván Cavero-Redondo Irene Martínez-García Eva Rodríguez-Gutiérrez Maribel Lucerón-Lucas-Torres Nerea Moreno-Herráiz Valentina Díaz-Goñi Alicia Saz-Lara |
| author_facet | Carlos Pascual-Morena Iván Cavero-Redondo Irene Martínez-García Eva Rodríguez-Gutiérrez Maribel Lucerón-Lucas-Torres Nerea Moreno-Herráiz Valentina Díaz-Goñi Alicia Saz-Lara |
| author_sort | Carlos Pascual-Morena |
| collection | DOAJ |
| description | Previous evidence associates insulin resistance with arterial stiffness in various pathologies, yet limited reports exist in healthy adults. Therefore, this study aims to estimate the association between insulin resistance and arterial stiffness in healthy adults. The cross-sectional EVasCu study enrolled 390 participants (42.05 ± 13.15 years). ANCOVAs, unadjusted (model 1) and adjusted (model 2), explored the association between arterial stiffness markers (aortic Pulse Wave Velocity [aPWV], Augmentation Index [AIx@75] and Cardio-Ankle Vascular Index [CAVI]), and insulin resistance markers (Homeostasis Model Assessment of Insulin Resistance [HOMA-IR], Quantitative Insulin Sensitivity Check Index [QUICKI] and Triglycerides-Glucose [TyG]). In model 1, all insulin resistance markers were associated with aPWV, HOMA-IR and QUICKI were associated with AIx@75, and the TyG index was associated with CAVI. In model 2, HOMA-IR and QUICKI increased aPWV by 0.179 and 0.156 m/s (<i>p</i> = 0.001 and <i>p</i> = 0.011), and AIx@75 by 4.17 and 5.39% (<i>p</i> = 0.009 and <i>p</i> = 0.003). The EVasCu study offers valuable insights into the relationship between insulin resistance and arterial stiffness in healthy adults, providing a deeper understanding of metabolic and cardiovascular health. By examining this influence, we embark on an intriguing exploration of how these factors interplay in the human body. |
| first_indexed | 2024-04-24T17:56:58Z |
| format | Article |
| id | doaj.art-29e47c557fcf42258e3d03a7b8d0e979 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T17:56:58Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-29e47c557fcf42258e3d03a7b8d0e9792024-03-27T13:58:06ZengMDPI AGNutrients2072-66432024-03-0116679110.3390/nu16060791Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu StudyCarlos Pascual-Morena0Iván Cavero-Redondo1Irene Martínez-García2Eva Rodríguez-Gutiérrez3Maribel Lucerón-Lucas-Torres4Nerea Moreno-Herráiz5Valentina Díaz-Goñi6Alicia Saz-Lara7Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainFacultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 3460000, ChileHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainHealth and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, SpainPrevious evidence associates insulin resistance with arterial stiffness in various pathologies, yet limited reports exist in healthy adults. Therefore, this study aims to estimate the association between insulin resistance and arterial stiffness in healthy adults. The cross-sectional EVasCu study enrolled 390 participants (42.05 ± 13.15 years). ANCOVAs, unadjusted (model 1) and adjusted (model 2), explored the association between arterial stiffness markers (aortic Pulse Wave Velocity [aPWV], Augmentation Index [AIx@75] and Cardio-Ankle Vascular Index [CAVI]), and insulin resistance markers (Homeostasis Model Assessment of Insulin Resistance [HOMA-IR], Quantitative Insulin Sensitivity Check Index [QUICKI] and Triglycerides-Glucose [TyG]). In model 1, all insulin resistance markers were associated with aPWV, HOMA-IR and QUICKI were associated with AIx@75, and the TyG index was associated with CAVI. In model 2, HOMA-IR and QUICKI increased aPWV by 0.179 and 0.156 m/s (<i>p</i> = 0.001 and <i>p</i> = 0.011), and AIx@75 by 4.17 and 5.39% (<i>p</i> = 0.009 and <i>p</i> = 0.003). The EVasCu study offers valuable insights into the relationship between insulin resistance and arterial stiffness in healthy adults, providing a deeper understanding of metabolic and cardiovascular health. By examining this influence, we embark on an intriguing exploration of how these factors interplay in the human body.https://www.mdpi.com/2072-6643/16/6/791insulin resistancevascular stiffnesspulse wave analysiscardiovascular healthendocrinologymetabolism |
| spellingShingle | Carlos Pascual-Morena Iván Cavero-Redondo Irene Martínez-García Eva Rodríguez-Gutiérrez Maribel Lucerón-Lucas-Torres Nerea Moreno-Herráiz Valentina Díaz-Goñi Alicia Saz-Lara Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study Nutrients insulin resistance vascular stiffness pulse wave analysis cardiovascular health endocrinology metabolism |
| title | Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study |
| title_full | Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study |
| title_fullStr | Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study |
| title_full_unstemmed | Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study |
| title_short | Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study |
| title_sort | exploring the influence of insulin resistance on arterial stiffness in healthy adults from the metabolic and cardiovascular health insights of the evascu study |
| topic | insulin resistance vascular stiffness pulse wave analysis cardiovascular health endocrinology metabolism |
| url | https://www.mdpi.com/2072-6643/16/6/791 |
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