Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces
Indwelling urinary catheterization can lead to the development of catheter-associated urinary tract infections (CAUTIs), an important type of nosocomial infection, as well as other medical issues among institutionalized adults. Recently, Proteus mirabilis was highlighted as the important cause of CA...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.864305/full |
| _version_ | 1818474984200208384 |
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| author | Dawid Gmiter Wieslaw Kaca |
| author_facet | Dawid Gmiter Wieslaw Kaca |
| author_sort | Dawid Gmiter |
| collection | DOAJ |
| description | Indwelling urinary catheterization can lead to the development of catheter-associated urinary tract infections (CAUTIs), an important type of nosocomial infection, as well as other medical issues among institutionalized adults. Recently, Proteus mirabilis was highlighted as the important cause of CAUTIs. The pathogenicity of P. mirabilis is dependent on two multicellular types of surface colonization: the adherence and swarming motility. Adhesion, mostly mediated by fimbrial and nonfimbrial adhesins, is important for the initiation of biofilm formation. Moreover, the production of urease frequently results in biofilm crystallization, which leads to the blockage of catheters. The heterologous polymeric matrix of the biofilm offers protection against antibiotics and the host immune system. P. mirabilis displays remarkable motility abilities. After contact with solid surfaces, hyper-flagellated cells are able to rapidly migrate. The importance of swarming motility in CAUTIs development remains controversial; however, it was indicated that swarming cells were able to co-express other virulence factors. Furthermore, flagella are strong immunomodulating proteins. On the other hand, both biofilm formation and swarming motility implicates multiple inter- and intraspecies interactions, which might contribute to the pathogenicity. |
| first_indexed | 2024-04-14T04:43:23Z |
| format | Article |
| id | doaj.art-29e6673a611f43b1a46db89869952089 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-14T04:43:23Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-29e6673a611f43b1a46db898699520892022-12-22T02:11:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-09-011210.3389/fcimb.2022.864305864305Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfacesDawid GmiterWieslaw KacaIndwelling urinary catheterization can lead to the development of catheter-associated urinary tract infections (CAUTIs), an important type of nosocomial infection, as well as other medical issues among institutionalized adults. Recently, Proteus mirabilis was highlighted as the important cause of CAUTIs. The pathogenicity of P. mirabilis is dependent on two multicellular types of surface colonization: the adherence and swarming motility. Adhesion, mostly mediated by fimbrial and nonfimbrial adhesins, is important for the initiation of biofilm formation. Moreover, the production of urease frequently results in biofilm crystallization, which leads to the blockage of catheters. The heterologous polymeric matrix of the biofilm offers protection against antibiotics and the host immune system. P. mirabilis displays remarkable motility abilities. After contact with solid surfaces, hyper-flagellated cells are able to rapidly migrate. The importance of swarming motility in CAUTIs development remains controversial; however, it was indicated that swarming cells were able to co-express other virulence factors. Furthermore, flagella are strong immunomodulating proteins. On the other hand, both biofilm formation and swarming motility implicates multiple inter- and intraspecies interactions, which might contribute to the pathogenicity.https://www.frontiersin.org/articles/10.3389/fcimb.2022.864305/fullProteus mirabilisswarming motilitybiofiolmurinary tract infections (UTIs)bacterial interactions |
| spellingShingle | Dawid Gmiter Wieslaw Kaca Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces Frontiers in Cellular and Infection Microbiology Proteus mirabilis swarming motility biofiolm urinary tract infections (UTIs) bacterial interactions |
| title | Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces |
| title_full | Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces |
| title_fullStr | Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces |
| title_full_unstemmed | Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces |
| title_short | Into the understanding the multicellular lifestyle of Proteus mirabilis on solid surfaces |
| title_sort | into the understanding the multicellular lifestyle of proteus mirabilis on solid surfaces |
| topic | Proteus mirabilis swarming motility biofiolm urinary tract infections (UTIs) bacterial interactions |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.864305/full |
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