Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.

Background: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Elut...

Full description

Bibliographic Details
Main Author: Khaled Alsayed
Format: Article
Language:English
Published: Al-Azhar University, Faculty of Medicine (Damietta) 2020-10-01
Series:International Journal of Medical Arts
Subjects:
Online Access:https://ijma.journals.ekb.eg/article_107606_8b9c1c1c3d00af5de46963c710e86f87.pdf
_version_ 1818751999443730432
author Khaled Alsayed
author_facet Khaled Alsayed
author_sort Khaled Alsayed
collection DOAJ
description Background: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Eluting Stents [ZES], and A Everolimus-Eluting Stents [EES]] in patients undergoing percutaneous coronary intervention. Patients and Methods: 160 Ischemic Heart Disease [IHD] patients undergoing PCI with 2nd generation DES implantation [80 ZES and 80 EES] were analyzed against 50 IHD patients undergoing PCI with BMS implantation. Each patients group received up to 6 [in BMS group] or 24 months [in ZES and EES groups] of clopidogrel therapy. The key efficacy endpoint was the 24 months major adverse cardiac event [MACE] [death, myocardial infarction, or target lesion revascularization], whereas stent thrombosis [ST] was the safety endpoint. Results: The MACE rate was lowest in EES [19%; χ2= 7.661], highest in BMS [41.7%; χ2 =7.661], and intermediate in ZES [28.2%; χ2= 7.661] group with significant P Value =0.002.The 2-year incidence of ST in the EES group [1.3%] was similar to that in the ZES-S group [2.2%], whereas it was lower in contrast with BMS [7.5%] groups, with significant P value= 0.004]. Conclusion: DES have more efficacy and safety than BMS as EES have lowest MACE and ST rate while BMS have the highest rate and ZES have intermediate rate while the three stent groups have similar rate of mortality at 2 years follow up.
first_indexed 2024-12-18T04:44:29Z
format Article
id doaj.art-29e6dff8e4cd4a0fb946a5a897b58084
institution Directory Open Access Journal
issn 2636-4174
2682-3780
language English
last_indexed 2024-12-18T04:44:29Z
publishDate 2020-10-01
publisher Al-Azhar University, Faculty of Medicine (Damietta)
record_format Article
series International Journal of Medical Arts
spelling doaj.art-29e6dff8e4cd4a0fb946a5a897b580842022-12-21T21:20:36ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802020-10-012478679210.21608/ijma.2020.35338.1145107606Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.Khaled Alsayed0Cardiology, faculty of medecin, Al azhar University, Assiut branchBackground: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Eluting Stents [ZES], and A Everolimus-Eluting Stents [EES]] in patients undergoing percutaneous coronary intervention. Patients and Methods: 160 Ischemic Heart Disease [IHD] patients undergoing PCI with 2nd generation DES implantation [80 ZES and 80 EES] were analyzed against 50 IHD patients undergoing PCI with BMS implantation. Each patients group received up to 6 [in BMS group] or 24 months [in ZES and EES groups] of clopidogrel therapy. The key efficacy endpoint was the 24 months major adverse cardiac event [MACE] [death, myocardial infarction, or target lesion revascularization], whereas stent thrombosis [ST] was the safety endpoint. Results: The MACE rate was lowest in EES [19%; χ2= 7.661], highest in BMS [41.7%; χ2 =7.661], and intermediate in ZES [28.2%; χ2= 7.661] group with significant P Value =0.002.The 2-year incidence of ST in the EES group [1.3%] was similar to that in the ZES-S group [2.2%], whereas it was lower in contrast with BMS [7.5%] groups, with significant P value= 0.004]. Conclusion: DES have more efficacy and safety than BMS as EES have lowest MACE and ST rate while BMS have the highest rate and ZES have intermediate rate while the three stent groups have similar rate of mortality at 2 years follow up.https://ijma.journals.ekb.eg/article_107606_8b9c1c1c3d00af5de46963c710e86f87.pdfbare metalzotarolimuseluting stentsmajor adverse cardiac eventsin stent restenosisstent thrombosis
spellingShingle Khaled Alsayed
Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
International Journal of Medical Arts
bare metal
zotarolimus
eluting stents
major adverse cardiac events
in stent restenosis
stent thrombosis
title Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_full Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_fullStr Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_full_unstemmed Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_short Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_sort comparison between a bare metal stents and drug eluting stents in patients undergoing percutaneous coronary intervention
topic bare metal
zotarolimus
eluting stents
major adverse cardiac events
in stent restenosis
stent thrombosis
url https://ijma.journals.ekb.eg/article_107606_8b9c1c1c3d00af5de46963c710e86f87.pdf
work_keys_str_mv AT khaledalsayed comparisonbetweenabaremetalstentsanddrugelutingstentsinpatientsundergoingpercutaneouscoronaryintervention