Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report
Abstract Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n ...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26223-w |
| _version_ | 1797865097351135232 |
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| author | Davide Garzone Jan Henrik Terheyden Olivier Morelle Maximilian W. M. Wintergerst Marlene Saßmannshausen Steffen Schmitz-Valckenberg Maximilian Pfau Sarah Thiele Stephen Poor Sergio Leal Frank G. Holz Robert P. Finger MACUSTAR Consortium |
| author_facet | Davide Garzone Jan Henrik Terheyden Olivier Morelle Maximilian W. M. Wintergerst Marlene Saßmannshausen Steffen Schmitz-Valckenberg Maximilian Pfau Sarah Thiele Stephen Poor Sergio Leal Frank G. Holz Robert P. Finger MACUSTAR Consortium |
| author_sort | Davide Garzone |
| collection | DOAJ |
| description | Abstract Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n = 126), early (eAMD, n = 25) or no AMD (n = 49) from the MACUSTAR study. We assessed OCT scans from Cirrus (200 × 200 macular cube, 6 × 6 mm; Zeiss Meditec, CA) and Spectralis (20° × 20°, 25 B-scans; 30° × 25°, 241 B-scans; Heidelberg Engineering, Germany) devices. Sensitivity and specificity for drusen detection and differences between modalities were assessed with intra-class correlation coefficients (ICCs) and mean difference in a 5 mm diameter fovea-centered circle. Specificity was > 90% in the three modalities. In eAMD, we observed highest sensitivity in the denser Spectralis scan (68.1). The two different Spectralis modalities showed a significantly higher agreement in quantifying drusen volume in iAMD (ICC 0.993 [0.991–0.994]) than the dense Spectralis with Cirrus scan (ICC 0.807 [0.757–0.847]). Formulae for drusen volume conversion in iAMD between the two devices are provided. Automated drusen volume measures are not interchangeable between devices and softwares and need to be interpreted with the used imaging devices and software in mind. Accounting for systematic difference between methods increases comparability and conversion formulae are provided. Less dense scans did not affect drusen volume measurements in iAMD but decreased sensitivity for medium drusen in eAMD. Trial registration: ClinicalTrials.gov NCT03349801. Registered on 22 November 2017. |
| first_indexed | 2024-04-09T23:03:50Z |
| format | Article |
| id | doaj.art-29e756f5d1034584915d1208b2514c47 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:03:50Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-29e756f5d1034584915d1208b2514c472023-03-22T10:50:28ZengNature PortfolioScientific Reports2045-23222022-12-0112111010.1038/s41598-022-26223-wComparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study reportDavide Garzone0Jan Henrik Terheyden1Olivier Morelle2Maximilian W. M. Wintergerst3Marlene Saßmannshausen4Steffen Schmitz-Valckenberg5Maximilian Pfau6Sarah Thiele7Stephen Poor8Sergio Leal9Frank G. Holz10Robert P. Finger11MACUSTAR ConsortiumDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnOphthalmology, Novartis Institutes for Biomedical ResearchBayer PharmaceuticalsDepartment of Ophthalmology, University Hospital BonnDepartment of Ophthalmology, University Hospital BonnAbstract Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n = 126), early (eAMD, n = 25) or no AMD (n = 49) from the MACUSTAR study. We assessed OCT scans from Cirrus (200 × 200 macular cube, 6 × 6 mm; Zeiss Meditec, CA) and Spectralis (20° × 20°, 25 B-scans; 30° × 25°, 241 B-scans; Heidelberg Engineering, Germany) devices. Sensitivity and specificity for drusen detection and differences between modalities were assessed with intra-class correlation coefficients (ICCs) and mean difference in a 5 mm diameter fovea-centered circle. Specificity was > 90% in the three modalities. In eAMD, we observed highest sensitivity in the denser Spectralis scan (68.1). The two different Spectralis modalities showed a significantly higher agreement in quantifying drusen volume in iAMD (ICC 0.993 [0.991–0.994]) than the dense Spectralis with Cirrus scan (ICC 0.807 [0.757–0.847]). Formulae for drusen volume conversion in iAMD between the two devices are provided. Automated drusen volume measures are not interchangeable between devices and softwares and need to be interpreted with the used imaging devices and software in mind. Accounting for systematic difference between methods increases comparability and conversion formulae are provided. Less dense scans did not affect drusen volume measurements in iAMD but decreased sensitivity for medium drusen in eAMD. Trial registration: ClinicalTrials.gov NCT03349801. Registered on 22 November 2017.https://doi.org/10.1038/s41598-022-26223-w |
| spellingShingle | Davide Garzone Jan Henrik Terheyden Olivier Morelle Maximilian W. M. Wintergerst Marlene Saßmannshausen Steffen Schmitz-Valckenberg Maximilian Pfau Sarah Thiele Stephen Poor Sergio Leal Frank G. Holz Robert P. Finger MACUSTAR Consortium Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report Scientific Reports |
| title | Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report |
| title_full | Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report |
| title_fullStr | Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report |
| title_full_unstemmed | Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report |
| title_short | Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report |
| title_sort | comparability of automated drusen volume measurements in age related macular degeneration a macustar study report |
| url | https://doi.org/10.1038/s41598-022-26223-w |
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