ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL
Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a remarkable achievement in the treatment against malaria. Since its discovery in the 1970’s, researchers readily started synthesizing this complex natural product containing an unusual endoperoxide fragment....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2022-09-01
|
| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000700831&tlng=pt |
| _version_ | 1798001389677314048 |
|---|---|
| author | Ramon Guerra de Oliveira Luiza dos Reis Cruz Luiz Carlos Dias |
| author_facet | Ramon Guerra de Oliveira Luiza dos Reis Cruz Luiz Carlos Dias |
| author_sort | Ramon Guerra de Oliveira |
| collection | DOAJ |
| description | Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a remarkable achievement in the treatment against malaria. Since its discovery in the 1970’s, researchers readily started synthesizing this complex natural product containing an unusual endoperoxide fragment. Despite various total syntheses reported, only in the last decade the production jumped from extraction/bench scale to industrial manufacturing. In this sense, the objective of this contribution is to highlight the discovery, the most representative works towards the synthesis of artemisinin and its main derivatives used worldwide against malaria, and the path to the industrial production of these compounds. |
| first_indexed | 2024-04-11T11:35:29Z |
| format | Article |
| id | doaj.art-29e82d472d4444f0aa959c6189011949 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-11T11:35:29Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-29e82d472d4444f0aa959c61890119492022-12-22T04:25:58ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642022-09-0145783184610.21577/0100-4042.20170888ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIALRamon Guerra de Oliveirahttps://orcid.org/0000-0002-2407-5766Luiza dos Reis Cruzhttps://orcid.org/0000-0001-6103-9345Luiz Carlos Diashttps://orcid.org/0000-0003-0628-9928Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a remarkable achievement in the treatment against malaria. Since its discovery in the 1970’s, researchers readily started synthesizing this complex natural product containing an unusual endoperoxide fragment. Despite various total syntheses reported, only in the last decade the production jumped from extraction/bench scale to industrial manufacturing. In this sense, the objective of this contribution is to highlight the discovery, the most representative works towards the synthesis of artemisinin and its main derivatives used worldwide against malaria, and the path to the industrial production of these compounds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000700831&tlng=ptendoperoxidetotal synthesisterpenoidsmalaria |
| spellingShingle | Ramon Guerra de Oliveira Luiza dos Reis Cruz Luiz Carlos Dias ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL Química Nova endoperoxide total synthesis terpenoids malaria |
| title | ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL |
| title_full | ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL |
| title_fullStr | ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL |
| title_full_unstemmed | ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL |
| title_short | ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL |
| title_sort | artemisinina e derivados descoberta estrategias sinteticas e obtencao industrial |
| topic | endoperoxide total synthesis terpenoids malaria |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000700831&tlng=pt |
| work_keys_str_mv | AT ramonguerradeoliveira artemisininaederivadosdescobertaestrategiassinteticaseobtencaoindustrial AT luizadosreiscruz artemisininaederivadosdescobertaestrategiassinteticaseobtencaoindustrial AT luizcarlosdias artemisininaederivadosdescobertaestrategiassinteticaseobtencaoindustrial |