Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media
Objective To investigate the distribution of multidrug-resistant organisms (MDRO) and other pathogens in the patients with chronic suppurative otitis media(CSOM) to provide evidence for prevention and treatment of CSOM. Methods: A total of 224 patients with CSOM were enrolled from January 2016 to Ma...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Diagnostics Concepts & Practice
2021-02-01
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| Series: | Zhenduanxue lilun yu shijian |
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| Online Access: | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1671-2870-2021-20-1-88.pdf |
| _version_ | 1828085009340170240 |
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| author | WANG Anqi, WANG Shili, LANG Juntian, XIANG Mingliang |
| author_facet | WANG Anqi, WANG Shili, LANG Juntian, XIANG Mingliang |
| author_sort | WANG Anqi, WANG Shili, LANG Juntian, XIANG Mingliang |
| collection | DOAJ |
| description | Objective To investigate the distribution of multidrug-resistant organisms (MDRO) and other pathogens in the patients with chronic suppurative otitis media(CSOM) to provide evidence for prevention and treatment of CSOM. Methods: A total of 224 patients with CSOM were enrolled from January 2016 to March 2020. The samples of ear secretion were obtained for bacterial culture and isolating pathogen, and the test of drug sensitivity was conducted. Results: The samples from 177 patients (78.57%) were positive in bacterial culture and a total of 215 strains were detected, inclu-ding 72 strains of gram-positive bacteria(72/215, 33.49%), 19 strains of gram-negative bacteria (19/215, 8.84%), 124 strains of fungi(124/215, 57.67%). Among 215 strains, 36 strains of MDRO(36/215, 16.74%) were isolated, including 20 strains of Staphylococcus aureus(20/36, 55.56%), 12 strains of coagulase negative Staphylococcus(CoNS)(12/36, 33.33%) and 2 strains of Pseudomonasaeruginosa (2/36, 5.56%). Staphylococcus aureus and CoNS had highest resistant rate to penicillin (95.10% and 64.29%), while Pseudomonas aeruginosa had highest resistant rate to levofloxacin(62.50%). The statistical analysis revealed that empirical antibiotic treatment was an independent risk factor of MDRO infection (P<0.05), and the fungal infectionin patients had no relationship with empirical antibiotic treatment, gender or age. Conclusions: Fungal infection is the main cause for local CSOM. The bacterial culture combined with the test of drug sensitivity are essential for treatment of CSOM, and empirical antibiotic treatment should be avoided to use to reduce MDRO infection. |
| first_indexed | 2024-04-11T04:33:22Z |
| format | Article |
| id | doaj.art-29e94307585648b18b8f0279a61c47cf |
| institution | Directory Open Access Journal |
| issn | 1671-2870 |
| language | zho |
| last_indexed | 2024-04-11T04:33:22Z |
| publishDate | 2021-02-01 |
| publisher | Editorial Office of Journal of Diagnostics Concepts & Practice |
| record_format | Article |
| series | Zhenduanxue lilun yu shijian |
| spelling | doaj.art-29e94307585648b18b8f0279a61c47cf2022-12-29T00:57:37ZzhoEditorial Office of Journal of Diagnostics Concepts & PracticeZhenduanxue lilun yu shijian1671-28702021-02-012001889210.16150/j.1671-2870.2021.01.014Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis mediaWANG Anqi, WANG Shili, LANG Juntian, XIANG Mingliang0Department of Otolaryngology, North Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, ChinaObjective To investigate the distribution of multidrug-resistant organisms (MDRO) and other pathogens in the patients with chronic suppurative otitis media(CSOM) to provide evidence for prevention and treatment of CSOM. Methods: A total of 224 patients with CSOM were enrolled from January 2016 to March 2020. The samples of ear secretion were obtained for bacterial culture and isolating pathogen, and the test of drug sensitivity was conducted. Results: The samples from 177 patients (78.57%) were positive in bacterial culture and a total of 215 strains were detected, inclu-ding 72 strains of gram-positive bacteria(72/215, 33.49%), 19 strains of gram-negative bacteria (19/215, 8.84%), 124 strains of fungi(124/215, 57.67%). Among 215 strains, 36 strains of MDRO(36/215, 16.74%) were isolated, including 20 strains of Staphylococcus aureus(20/36, 55.56%), 12 strains of coagulase negative Staphylococcus(CoNS)(12/36, 33.33%) and 2 strains of Pseudomonasaeruginosa (2/36, 5.56%). Staphylococcus aureus and CoNS had highest resistant rate to penicillin (95.10% and 64.29%), while Pseudomonas aeruginosa had highest resistant rate to levofloxacin(62.50%). The statistical analysis revealed that empirical antibiotic treatment was an independent risk factor of MDRO infection (P<0.05), and the fungal infectionin patients had no relationship with empirical antibiotic treatment, gender or age. Conclusions: Fungal infection is the main cause for local CSOM. The bacterial culture combined with the test of drug sensitivity are essential for treatment of CSOM, and empirical antibiotic treatment should be avoided to use to reduce MDRO infection.http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1671-2870-2021-20-1-88.pdf|chronic suppurative otitis media|multi drug resistant organisms|empirical treatment |
| spellingShingle | WANG Anqi, WANG Shili, LANG Juntian, XIANG Mingliang Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media Zhenduanxue lilun yu shijian |chronic suppurative otitis media|multi drug resistant organisms|empirical treatment |
| title | Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media |
| title_full | Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media |
| title_fullStr | Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media |
| title_full_unstemmed | Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media |
| title_short | Analysis of antibiotic resistant bacteria and multidrug-resistant organisms isolated from patients with chronic suppurative otitis media |
| title_sort | analysis of antibiotic resistant bacteria and multidrug resistant organisms isolated from patients with chronic suppurative otitis media |
| topic | |chronic suppurative otitis media|multi drug resistant organisms|empirical treatment |
| url | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1671-2870-2021-20-1-88.pdf |
| work_keys_str_mv | AT wanganqiwangshililangjuntianxiangmingliang analysisofantibioticresistantbacteriaandmultidrugresistantorganismsisolatedfrompatientswithchronicsuppurativeotitismedia |