Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Advances in Rheumatology |
| Online Access: | https://doi.org/10.1186/s42358-021-00228-x |
| _version_ | 1828978954085597184 |
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| author | Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier |
| author_facet | Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier |
| author_sort | Karina Rossi Bonfiglioli |
| collection | DOAJ |
| description | Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017. |
| first_indexed | 2024-12-14T15:28:56Z |
| format | Article |
| id | doaj.art-29eb58b890394fa49f3e3b5912989336 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-14T15:28:56Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-29eb58b890394fa49f3e3b59129893362022-12-21T22:55:57ZengBMCAdvances in Rheumatology2523-31062021-11-0161111310.1186/s42358-021-00228-xRecommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritisKarina Rossi Bonfiglioli0Licia Maria Henrique da Mota1Ana Cristina de Medeiros Ribeiro2Adriana Maria Kakehasi3Ieda Maria Magalhães Laurindo4Rina Dalva Neubarth Giorgi5Angela Luzia Branco Pinto Duarte6Ana Paula Monteiro Gomides Reis7Mariana Peixoto Guimarães Ubirajara e Silva de Souza8Claiton Viegas Brenol9Geraldo da Rocha Castelar Pinheiro10Cleandro Pires de Albuquerque11Charlles Heldan de Moura Castro12Gustavo Luiz Behrens Pinto13Jose Fernando Verztman14Luciana Feitosa Muniz15Manoel Barros Bertolo16Maria Raquel da Costa Pinto17Paulo Louzada Júnior18Vitor Alves Cruz19Ivanio Alves Pereira20Max Vitor Carioca de Freitas21Bóris Afonso Cruz22Eduardo Paiva23Odirlei Monticielo24José Roberto Provenza25Ricardo Machado Xavier26Disciplina Reumatologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP)Serviço de Reumatologia do Hospital, Universitário de Brasília (HUB/UnB)Disciplina Reumatologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP)Serviço de Reumatologia, Universidade Federal de Minas Gerais (UFMG)Disciplina de Reumatologia, Universidade Nove de Julho (UNINOVE)Serviço de Reumatologia, Hospital do Servidor Público Estadual de São Paulo (HSPE-IAMSPE)Universidade Federal de Pernambuco (UFPE)Serviço de Reumatologia do Hospital, Universitário de Brasília (HUB/UnB)Santa Casa de Belo Horizonte (MG)Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (HCPA/UFRGS)Universidade do Estado do Rio de Janeiro (UERJ)Serviço de Reumatologia do Hospital, Universitário de Brasília (HUB/UnB)Escola Paulista de Medicina, Universidade Federal de São PauloUniversidade Federal da Bahia (UFBA)Hospital Federal dos Servidores do Estado do RJHospital Regional de Sobradinho (DF)Disciplina de Reumatologia, Faculdade de Ciências Médicas, Universidade Estadual de CampinasServiço de Reumatologia, Universidade Federal de Minas Gerais (UFMG)Disciplina de Reumatologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP-RP)Disciplina de Reumatologia, Faculdade de Medicina, Universidade Federal de GoiásServiço de Reumatologia do Hospital Universitário, Universidade Federal de Santa Catarina-UFSCUniversidade de Fortaleza - UNIFORPulsus – Belo Horizonte (MG)Disciplina de Reumatologia, Universidade Federal do Paraná (UFPR)Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (HCPA/UFRGS)Disciplina de Reumatologia da Pontificia, Universidade Católica de CampinasHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (HCPA/UFRGS)Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.https://doi.org/10.1186/s42358-021-00228-x |
| spellingShingle | Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis Advances in Rheumatology |
| title | Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis |
| title_full | Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis |
| title_fullStr | Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis |
| title_full_unstemmed | Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis |
| title_short | Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis |
| title_sort | recommendations of the brazilian society of rheumatology for the use of jak inhibitors in the management of rheumatoid arthritis |
| url | https://doi.org/10.1186/s42358-021-00228-x |
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