The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals
Sodium hypochlorite is the active ingredient in the antiseptic “Vitosept”. The pharmacological activity of the newly created drug is due to Oxygen, which is released in the active state by the decomposition of unstable hydrochloric acid into hydrochloric acid. A study of the antiseptic effect of the...
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| Format: | Article |
| Language: | English |
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Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv
2022-05-01
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| Series: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки |
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| Online Access: | https://nvlvet.com.ua/index.php/journal/article/view/4314 |
| _version_ | 1811339239112048640 |
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| author | M. P. Soltys H. V. Rudyk O. M. Brezvyn V. M. Hunchak B. V. Gutyj A. V. Hunchak R. O. Vasiv |
| author_facet | M. P. Soltys H. V. Rudyk O. M. Brezvyn V. M. Hunchak B. V. Gutyj A. V. Hunchak R. O. Vasiv |
| author_sort | M. P. Soltys |
| collection | DOAJ |
| description | Sodium hypochlorite is the active ingredient in the antiseptic “Vitosept”. The pharmacological activity of the newly created drug is due to Oxygen, which is released in the active state by the decomposition of unstable hydrochloric acid into hydrochloric acid. A study of the antiseptic effect of the drug Vitosept, conducted on a model of stencil wounds in laboratory rats, found that the speed of healing and reducing the area of skin damage in animals was not inferior to the effectiveness of the comparison drug “Dioxisol-Darnytsia”. According to the obtained results, the latter's use is more appropriate in the first phase of the wound process. In contrast, the use of “Vitosept” in the second and third phases provided acceleration of the formation of mature granulation tissue. In the experimental wounds, proliferative processes were accelerated, and connective tissue was formed with the appearance of a soft scar. The efficacy of Vitosept in the treatment of spontaneously infected wounds has been studied in dogs. For three days from the beginning of treatment in dogs, the general condition improved, body temperature decreased to 38.6 ± 0.3 °C, heart rate was 74 ± 0.6 beats/min, respiratory movements 16 ± 0.4. Positive changes were also observed in the study of wounds. Significant changes in the condition of the injuries were found on the 5th day from the start of treatment. During this period, the general condition of the animals returned to normal, body temperature, heart rate, and respiration was within physiological values. In the dogs of the experimental group, Vitosept showed a slowing of the inflammatory reaction, which was manifested by a decrease in swelling and a reduction in local temperature. The pain was still partially preserved. The amount of purulent exudate decreased significantly. The surfaces of the torn and torn wounds were covered with a small amount of exudate of liquid consistency with detritus impurities, the pH of the wound medium was 6.8 ± 0.1. The surface of the cut wounds was unevenly covered with bright red granulation tissue. At the final stage of healing, both concentric scarring and planar epithelialization were observed. In most cases, in animals of the experimental group, there was concentric scarring, which ended in the formation of a relatively small scar. And only large wounds are healed by planar epithelialization, i.e., the appearance of a wide epithelial rim. In the case of infected wounds in dogs, the drug “Vitosept” compared to animals in the control group normalized morphological and biochemical parameters of blood – erythrocyte count, hemoglobin, blood protein, and its fractions aminotransferase activity in serum. There was a normalization of the values of the leukogram, which indicated the rehabilitation processes in the whole body. As a result of studying the therapeutic efficacy of Vitosept, it was found that its topical application, on average, by 3–4 days accelerated the healing process with the formation of mature granulation tissues and epithelialization in dogs with infected wounds and provided asepsis and normalization of the studied indicators in the recovery process. |
| first_indexed | 2024-04-13T18:23:21Z |
| format | Article |
| id | doaj.art-29edde4fa91f4c8bbca4d2fe53470b98 |
| institution | Directory Open Access Journal |
| issn | 2518-7554 2518-1327 |
| language | English |
| last_indexed | 2024-04-13T18:23:21Z |
| publishDate | 2022-05-01 |
| publisher | Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv |
| record_format | Article |
| series | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки |
| spelling | doaj.art-29edde4fa91f4c8bbca4d2fe53470b982022-12-22T02:35:20ZengStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies LvivНауковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки2518-75542518-13272022-05-0124105738210.32718/nvlvet105114314The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animalsM. P. Soltys0H. V. Rudyk1O. M. Brezvyn2V. M. Hunchak3B. V. Gutyj4A. V. Hunchak5R. O. Vasiv6Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, UkraineState Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives, Lviv, UkraineState Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives, Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, UkraineInstitute of Animal Biology of NAAS, Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, UkraineSodium hypochlorite is the active ingredient in the antiseptic “Vitosept”. The pharmacological activity of the newly created drug is due to Oxygen, which is released in the active state by the decomposition of unstable hydrochloric acid into hydrochloric acid. A study of the antiseptic effect of the drug Vitosept, conducted on a model of stencil wounds in laboratory rats, found that the speed of healing and reducing the area of skin damage in animals was not inferior to the effectiveness of the comparison drug “Dioxisol-Darnytsia”. According to the obtained results, the latter's use is more appropriate in the first phase of the wound process. In contrast, the use of “Vitosept” in the second and third phases provided acceleration of the formation of mature granulation tissue. In the experimental wounds, proliferative processes were accelerated, and connective tissue was formed with the appearance of a soft scar. The efficacy of Vitosept in the treatment of spontaneously infected wounds has been studied in dogs. For three days from the beginning of treatment in dogs, the general condition improved, body temperature decreased to 38.6 ± 0.3 °C, heart rate was 74 ± 0.6 beats/min, respiratory movements 16 ± 0.4. Positive changes were also observed in the study of wounds. Significant changes in the condition of the injuries were found on the 5th day from the start of treatment. During this period, the general condition of the animals returned to normal, body temperature, heart rate, and respiration was within physiological values. In the dogs of the experimental group, Vitosept showed a slowing of the inflammatory reaction, which was manifested by a decrease in swelling and a reduction in local temperature. The pain was still partially preserved. The amount of purulent exudate decreased significantly. The surfaces of the torn and torn wounds were covered with a small amount of exudate of liquid consistency with detritus impurities, the pH of the wound medium was 6.8 ± 0.1. The surface of the cut wounds was unevenly covered with bright red granulation tissue. At the final stage of healing, both concentric scarring and planar epithelialization were observed. In most cases, in animals of the experimental group, there was concentric scarring, which ended in the formation of a relatively small scar. And only large wounds are healed by planar epithelialization, i.e., the appearance of a wide epithelial rim. In the case of infected wounds in dogs, the drug “Vitosept” compared to animals in the control group normalized morphological and biochemical parameters of blood – erythrocyte count, hemoglobin, blood protein, and its fractions aminotransferase activity in serum. There was a normalization of the values of the leukogram, which indicated the rehabilitation processes in the whole body. As a result of studying the therapeutic efficacy of Vitosept, it was found that its topical application, on average, by 3–4 days accelerated the healing process with the formation of mature granulation tissues and epithelialization in dogs with infected wounds and provided asepsis and normalization of the studied indicators in the recovery process.https://nvlvet.com.ua/index.php/journal/article/view/4314rats, dogs, vitosept, dioksizol-darnytsia, blood, therapy |
| spellingShingle | M. P. Soltys H. V. Rudyk O. M. Brezvyn V. M. Hunchak B. V. Gutyj A. V. Hunchak R. O. Vasiv The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки rats, dogs, vitosept, dioksizol-darnytsia, blood, therapy |
| title | The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| title_full | The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| title_fullStr | The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| title_full_unstemmed | The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| title_short | The antiseptic activity of the drug, based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| title_sort | antiseptic activity of the drug based on sodium hypochlorite in experimental and spontaneously infected wounds in animals |
| topic | rats, dogs, vitosept, dioksizol-darnytsia, blood, therapy |
| url | https://nvlvet.com.ua/index.php/journal/article/view/4314 |
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