Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy
Breast cancer is the most prevalent cancer with an unfavorable prognosis in women, which seriously threatened women’s health worldwide. In our previous study, a phytoconstituent, panaxytriol (PA), isolated from a Tujia ethnomedicine Panax japonicus, showed excellent inhibitory effects on APE1 activi...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522008413 |
| _version_ | 1811192872815296512 |
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| author | Qian Xie Bin Li Jialong Fan Jiahao Liang Sai Jiang Yan Qin Ling Jiang Jiao Cui Xiaoping Nie Shaoqiu Sun Bin Liu Wei Wang |
| author_facet | Qian Xie Bin Li Jialong Fan Jiahao Liang Sai Jiang Yan Qin Ling Jiang Jiao Cui Xiaoping Nie Shaoqiu Sun Bin Liu Wei Wang |
| author_sort | Qian Xie |
| collection | DOAJ |
| description | Breast cancer is the most prevalent cancer with an unfavorable prognosis in women, which seriously threatened women’s health worldwide. In our previous study, a phytoconstituent, panaxytriol (PA), isolated from a Tujia ethnomedicine Panax japonicus, showed excellent inhibitory effects on APE1 activity, an enzyme tightly related with the development of breast cancer. Considering the tumor cell-killing ability and poor bioavailability of PA in vivo, Prussian blue nanoparticles with dopamine surface modification were applied to enhance its therapeutic efficacy against breast cancer by combining with photodynamic agent of indocyanine green. The hybrid-cell membrane (microphage and erythrocyte membranes) camouflage of the nano-delivery system significantly improved the solubility and targeting ability to tumor regions with increased immune evasion. This Prussian blue nanoparticle-based biomimetic formulation, introduced via tail vein administration, was validated as an efficient PA delivery vehicle for inhibiting the growth of breast cancer xenografts in nude mice. Molecular experiments revealed that the antitumor activity was mediated through cell proliferation inhibition and apoptosis induction. Our results prove that comprehensive therapy combining PA with nanomaterials may provide an effective strategy for treating breast cancer in vivo. |
| first_indexed | 2024-04-11T23:58:15Z |
| format | Article |
| id | doaj.art-29edf9cc2bb94c25aaccda947c4a4af9 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-11T23:58:15Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-29edf9cc2bb94c25aaccda947c4a4af92022-12-22T03:56:17ZengElsevierMaterials & Design0264-12752022-11-01223111219Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapyQian Xie0Bin Li1Jialong Fan2Jiahao Liang3Sai Jiang4Yan Qin5Ling Jiang6Jiao Cui7Xiaoping Nie8Shaoqiu Sun9Bin Liu10Wei Wang11TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, ChinaCollege of Biology, Hunan University, Changsha 410082, ChinaCollege of Pharmacy, College of Integrative Medicine, Dalian Medical University, Dalian 116044, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; College of Biology, Hunan University, Changsha 410082, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, ChinaTCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; College of Biology, Hunan University, Changsha 410082, China; Corresponding authors at: TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; Corresponding authors at: TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.Breast cancer is the most prevalent cancer with an unfavorable prognosis in women, which seriously threatened women’s health worldwide. In our previous study, a phytoconstituent, panaxytriol (PA), isolated from a Tujia ethnomedicine Panax japonicus, showed excellent inhibitory effects on APE1 activity, an enzyme tightly related with the development of breast cancer. Considering the tumor cell-killing ability and poor bioavailability of PA in vivo, Prussian blue nanoparticles with dopamine surface modification were applied to enhance its therapeutic efficacy against breast cancer by combining with photodynamic agent of indocyanine green. The hybrid-cell membrane (microphage and erythrocyte membranes) camouflage of the nano-delivery system significantly improved the solubility and targeting ability to tumor regions with increased immune evasion. This Prussian blue nanoparticle-based biomimetic formulation, introduced via tail vein administration, was validated as an efficient PA delivery vehicle for inhibiting the growth of breast cancer xenografts in nude mice. Molecular experiments revealed that the antitumor activity was mediated through cell proliferation inhibition and apoptosis induction. Our results prove that comprehensive therapy combining PA with nanomaterials may provide an effective strategy for treating breast cancer in vivo.http://www.sciencedirect.com/science/article/pii/S0264127522008413Breast cancerPanaxytriolPrussian blueHybrid-cell membranePanax japonicus |
| spellingShingle | Qian Xie Bin Li Jialong Fan Jiahao Liang Sai Jiang Yan Qin Ling Jiang Jiao Cui Xiaoping Nie Shaoqiu Sun Bin Liu Wei Wang Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy Materials & Design Breast cancer Panaxytriol Prussian blue Hybrid-cell membrane Panax japonicus |
| title | Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| title_full | Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| title_fullStr | Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| title_full_unstemmed | Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| title_short | Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| title_sort | biomimetic hybrid cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy |
| topic | Breast cancer Panaxytriol Prussian blue Hybrid-cell membrane Panax japonicus |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522008413 |
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