Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy
Abstract Recent reports revealed an increased rate of hospitalization and mortality of coronavirus disease 2019 (COVID‐19) among patients with psychiatric disorders. On the other hand, there is a link between latent infections, including Toxoplasma gondii, herpes simplex virus type 1 (HSV‐1) and cyt...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.141 |
| _version_ | 1797852188544860160 |
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| author | Mirza Ali Mofazzal Jahromi Mina Sefidfard Ali Taghipour Abazar Roustazadeh Sara Matin Hamed Mir Milad Badri Fares Bahrami Amir Abdoli |
| author_facet | Mirza Ali Mofazzal Jahromi Mina Sefidfard Ali Taghipour Abazar Roustazadeh Sara Matin Hamed Mir Milad Badri Fares Bahrami Amir Abdoli |
| author_sort | Mirza Ali Mofazzal Jahromi |
| collection | DOAJ |
| description | Abstract Recent reports revealed an increased rate of hospitalization and mortality of coronavirus disease 2019 (COVID‐19) among patients with psychiatric disorders. On the other hand, there is a link between latent infections, including Toxoplasma gondii, herpes simplex virus type 1 (HSV‐1) and cytomegalovirus (CMV) with psychiatric disorders. We individually assessed data regarding 1) the mortality rate of COVID‐19 among individuals with psychiatric disorders; 2) the association of latent infections in COVID‐19 patients and 3) the association between latent infections and psychiatric disorders. We developed the hypothesis that latent infection could increase the risk of severe COVID‐19 among patients with psychiatric disorders. Cumulative evidence proposed that infection with toxoplasmosis, CMV and HSV‐1 could increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS‐Co‐V2) infections among patients with psychiatric disorders probably by induction of hyperinflammatory conditions. These infections are also associated with hyperinflammation and T cell exhaustion, which has also been observed in both schizophrenia and COVID‐19. This hypothesis provides new insights into the role of latent infections in increasing the mortality rates of COVID‐19 among individuals with psychiatric disorders. Strategies for screening, early diagnosis and treatment of these infections could be recommended for COVID‐19 patients with a background of psychiatric disorders. |
| first_indexed | 2024-04-09T19:29:38Z |
| format | Article |
| id | doaj.art-29eea34fee4947afa775a1aa7b54599a |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-09T19:29:38Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-29eea34fee4947afa775a1aa7b54599a2023-04-05T04:47:06ZengWileyClinical and Translational Discovery2768-06222022-12-0124n/an/a10.1002/ctd2.141Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemyMirza Ali Mofazzal Jahromi0Mina Sefidfard1Ali Taghipour2Abazar Roustazadeh3Sara Matin4Hamed Mir5Milad Badri6Fares Bahrami7Amir Abdoli8Zoonoses Research Center Jahrom University of Medical Sciences Jahrom IranDepartment of Psychiatry Jahrom University of Medical Sciences Jahrom IranZoonoses Research Center Jahrom University of Medical Sciences Jahrom IranDepartment of Advanced Medical Sciences & Technologies Jahrom University of Medical Sciences Jahrom IranDepartment of Pediatrics Jahrom IranDepartment of Advanced Medical Sciences & Technologies Jahrom University of Medical Sciences Jahrom IranMedical Microbiology Research Center Qazvin University of Medical Sciences Qazvin IranKurdistan University of Medical Sciences Kurdistan IranZoonoses Research Center Jahrom University of Medical Sciences Jahrom IranAbstract Recent reports revealed an increased rate of hospitalization and mortality of coronavirus disease 2019 (COVID‐19) among patients with psychiatric disorders. On the other hand, there is a link between latent infections, including Toxoplasma gondii, herpes simplex virus type 1 (HSV‐1) and cytomegalovirus (CMV) with psychiatric disorders. We individually assessed data regarding 1) the mortality rate of COVID‐19 among individuals with psychiatric disorders; 2) the association of latent infections in COVID‐19 patients and 3) the association between latent infections and psychiatric disorders. We developed the hypothesis that latent infection could increase the risk of severe COVID‐19 among patients with psychiatric disorders. Cumulative evidence proposed that infection with toxoplasmosis, CMV and HSV‐1 could increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS‐Co‐V2) infections among patients with psychiatric disorders probably by induction of hyperinflammatory conditions. These infections are also associated with hyperinflammation and T cell exhaustion, which has also been observed in both schizophrenia and COVID‐19. This hypothesis provides new insights into the role of latent infections in increasing the mortality rates of COVID‐19 among individuals with psychiatric disorders. Strategies for screening, early diagnosis and treatment of these infections could be recommended for COVID‐19 patients with a background of psychiatric disorders.https://doi.org/10.1002/ctd2.141COVID‐19latent infectionspsychiatric disordersSARS‐CoV‐2 |
| spellingShingle | Mirza Ali Mofazzal Jahromi Mina Sefidfard Ali Taghipour Abazar Roustazadeh Sara Matin Hamed Mir Milad Badri Fares Bahrami Amir Abdoli Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy Clinical and Translational Discovery COVID‐19 latent infections psychiatric disorders SARS‐CoV‐2 |
| title | Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy |
| title_full | Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy |
| title_fullStr | Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy |
| title_full_unstemmed | Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy |
| title_short | Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy |
| title_sort | latent infections coronavirus disease 2019 and psychiatric disorders the friend of my enemy |
| topic | COVID‐19 latent infections psychiatric disorders SARS‐CoV‐2 |
| url | https://doi.org/10.1002/ctd2.141 |
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