Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet
Momordica charantia saponins (MCS) was supplemented to a high-starch diet to ssess the effect on the growth performance, glucose homeostasis modulating factors concerning the attenuated hyperglycemia, hyperlipemia and insulin resistance. Five iso-nitrogenous (30.48%) and iso-lipidic (5.41%) diets we...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Aquaculture Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513422002289 |
| _version_ | 1818490558008524800 |
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| author | Ze Fan Jinnan Li Di Wu Chenhui Li Dingchen Cao Linghong Miao Xianping Ge Liansheng Wang |
| author_facet | Ze Fan Jinnan Li Di Wu Chenhui Li Dingchen Cao Linghong Miao Xianping Ge Liansheng Wang |
| author_sort | Ze Fan |
| collection | DOAJ |
| description | Momordica charantia saponins (MCS) was supplemented to a high-starch diet to ssess the effect on the growth performance, glucose homeostasis modulating factors concerning the attenuated hyperglycemia, hyperlipemia and insulin resistance. Five iso-nitrogenous (30.48%) and iso-lipidic (5.41%) diets were formulated containing 30% starch (control group, HS), and were supplemented with 100 mg/kg (HS-MCS100), 400 mg/kg (HS-MCS400), 1600 mg/kg (HS-MCS1600) and 6400 mg/kg (HS-MCS6400) MCS on the basis of the HS diet. 450 common carp weighing (6.43 ± 0.02) g were randomly divided into 5 groups, with three replicates in each group and 30 fish in each replicate. Results revealed that dietary MCS effectively enhanced the growth and feed efficiency and significantly attenuated the glucose homeostasis and insulin resistance triggered by the HS diet. Moreover, 1600 mg/kg of MCS administration fulfilled more efficient and significant improvement of weight gain rate (WGR), specific growth rate (SGR), feed conversion rate (FCR), protein efficiency ratio (PER), protein and lipid deposition in the whole body. Alterations of serum biochemical indices revealed that 1600 mg/kg of MCS administration remarkably suppressed the hyperglycemia and hyperlipemia and elevated the insulin sensitivity. Enzyme activity and gene expression analysis of glycometabolism indicated that 1600 mg/kg of MCS administration could attenuate the hepatopancreas insulin resistance by enhancing glycolysis ability, promoting the glycogen synthesis and inhibiting the gluconeogenesis through activating PI3K/AKT signaling pathway. On all accounts detail, appropriate MCS administration have potential value in the alleviation of insulin resistance, thereby effectually maintain the glucose homeostasis and giving play to growth promoting effect for common carp fed with a high-carbohydrate diet. |
| first_indexed | 2024-12-10T17:18:39Z |
| format | Article |
| id | doaj.art-29f10489a3ce4154be0eba2346f4939c |
| institution | Directory Open Access Journal |
| issn | 2352-5134 |
| language | English |
| last_indexed | 2024-12-10T17:18:39Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj.art-29f10489a3ce4154be0eba2346f4939c2022-12-22T01:40:03ZengElsevierAquaculture Reports2352-51342022-08-0125101232Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch dietZe Fan0Jinnan Li1Di Wu2Chenhui Li3Dingchen Cao4Linghong Miao5Xianping Ge6Liansheng Wang7Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, ChinaKey Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, ChinaKey Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, ChinaKey Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, ChinaKey Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, ChinaKey Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, China; Correspondence to: Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070, China.Momordica charantia saponins (MCS) was supplemented to a high-starch diet to ssess the effect on the growth performance, glucose homeostasis modulating factors concerning the attenuated hyperglycemia, hyperlipemia and insulin resistance. Five iso-nitrogenous (30.48%) and iso-lipidic (5.41%) diets were formulated containing 30% starch (control group, HS), and were supplemented with 100 mg/kg (HS-MCS100), 400 mg/kg (HS-MCS400), 1600 mg/kg (HS-MCS1600) and 6400 mg/kg (HS-MCS6400) MCS on the basis of the HS diet. 450 common carp weighing (6.43 ± 0.02) g were randomly divided into 5 groups, with three replicates in each group and 30 fish in each replicate. Results revealed that dietary MCS effectively enhanced the growth and feed efficiency and significantly attenuated the glucose homeostasis and insulin resistance triggered by the HS diet. Moreover, 1600 mg/kg of MCS administration fulfilled more efficient and significant improvement of weight gain rate (WGR), specific growth rate (SGR), feed conversion rate (FCR), protein efficiency ratio (PER), protein and lipid deposition in the whole body. Alterations of serum biochemical indices revealed that 1600 mg/kg of MCS administration remarkably suppressed the hyperglycemia and hyperlipemia and elevated the insulin sensitivity. Enzyme activity and gene expression analysis of glycometabolism indicated that 1600 mg/kg of MCS administration could attenuate the hepatopancreas insulin resistance by enhancing glycolysis ability, promoting the glycogen synthesis and inhibiting the gluconeogenesis through activating PI3K/AKT signaling pathway. On all accounts detail, appropriate MCS administration have potential value in the alleviation of insulin resistance, thereby effectually maintain the glucose homeostasis and giving play to growth promoting effect for common carp fed with a high-carbohydrate diet.http://www.sciencedirect.com/science/article/pii/S2352513422002289Momordica charantia saponinsHigh-starch dietInsulin resistanceGlucose homeostasisHepatopancreasCommon carp |
| spellingShingle | Ze Fan Jinnan Li Di Wu Chenhui Li Dingchen Cao Linghong Miao Xianping Ge Liansheng Wang Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet Aquaculture Reports Momordica charantia saponins High-starch diet Insulin resistance Glucose homeostasis Hepatopancreas Common carp |
| title | Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet |
| title_full | Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet |
| title_fullStr | Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet |
| title_full_unstemmed | Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet |
| title_short | Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet |
| title_sort | preliminarily curative effectiveness of long term bitter melon momordica charantia saponins administration for the glucose homeostasis of juvenile common carp cyprinus carpio fed a high starch diet |
| topic | Momordica charantia saponins High-starch diet Insulin resistance Glucose homeostasis Hepatopancreas Common carp |
| url | http://www.sciencedirect.com/science/article/pii/S2352513422002289 |
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