The potential influence of melatonin on mitochondrial quality control: a review
Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of mitochondrial homeostasis and functional recovery after injury are coor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1332567/full |
| _version_ | 1827384178141822976 |
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| author | Xudan Lei Zhenni Xu Lingxiao Huang Yujun Huang Siyu Tu Lu Xu Dengqun Liu Dengqun Liu |
| author_facet | Xudan Lei Zhenni Xu Lingxiao Huang Yujun Huang Siyu Tu Lu Xu Dengqun Liu Dengqun Liu |
| author_sort | Xudan Lei |
| collection | DOAJ |
| description | Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of mitochondrial homeostasis and functional recovery after injury are coordinated by mitochondrial biogenesis, dynamics and autophagy, which are collectively referred to as mitochondrial quality control. There is increasing evidence that mitochondria are important targets for melatonin to exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported and metabolized in mitochondria. In this review, we summarize the important role of melatonin in the damaged mitochondria elimination and mitochondrial energy supply recovery by regulating mitochondrial quality control, which may provide new strategies for clinical treatment of mitochondria-related diseases. |
| first_indexed | 2024-03-08T14:50:58Z |
| format | Article |
| id | doaj.art-29f28da8549b43b98f1c740cad01750b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T14:50:58Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-29f28da8549b43b98f1c740cad01750b2024-01-11T04:13:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011410.3389/fphar.2023.13325671332567The potential influence of melatonin on mitochondrial quality control: a reviewXudan Lei0Zhenni Xu1Lingxiao Huang2Yujun Huang3Siyu Tu4Lu Xu5Dengqun Liu6Dengqun Liu7Radiation Oncology Key Laboratory of Sichuan Province, Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Department of Experimental Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaMitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of mitochondrial homeostasis and functional recovery after injury are coordinated by mitochondrial biogenesis, dynamics and autophagy, which are collectively referred to as mitochondrial quality control. There is increasing evidence that mitochondria are important targets for melatonin to exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported and metabolized in mitochondria. In this review, we summarize the important role of melatonin in the damaged mitochondria elimination and mitochondrial energy supply recovery by regulating mitochondrial quality control, which may provide new strategies for clinical treatment of mitochondria-related diseases.https://www.frontiersin.org/articles/10.3389/fphar.2023.1332567/fullautophagymelatoninmitochondrial dynamicsmitochondria-related diseasesoxidative phosphorylation |
| spellingShingle | Xudan Lei Zhenni Xu Lingxiao Huang Yujun Huang Siyu Tu Lu Xu Dengqun Liu Dengqun Liu The potential influence of melatonin on mitochondrial quality control: a review Frontiers in Pharmacology autophagy melatonin mitochondrial dynamics mitochondria-related diseases oxidative phosphorylation |
| title | The potential influence of melatonin on mitochondrial quality control: a review |
| title_full | The potential influence of melatonin on mitochondrial quality control: a review |
| title_fullStr | The potential influence of melatonin on mitochondrial quality control: a review |
| title_full_unstemmed | The potential influence of melatonin on mitochondrial quality control: a review |
| title_short | The potential influence of melatonin on mitochondrial quality control: a review |
| title_sort | potential influence of melatonin on mitochondrial quality control a review |
| topic | autophagy melatonin mitochondrial dynamics mitochondria-related diseases oxidative phosphorylation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1332567/full |
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