Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy
Objective: to study the characteristics of manifestations of hormonal abnormalities in women with juvenile myoclonic epilepsy (JME) and to comparatively analyze identified syndromes.Patients and methods. Hormonal disorders were analyzed in 48 reproductive-aged women with JME, who had received antiep...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2017-06-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/724 |
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| author | D. V. Anisimova R. V. Magzhanov P. N. Vlasov V. A. Petrukhin E. B. Tsevtsivadze S. R. Nurmukhametova |
| author_facet | D. V. Anisimova R. V. Magzhanov P. N. Vlasov V. A. Petrukhin E. B. Tsevtsivadze S. R. Nurmukhametova |
| author_sort | D. V. Anisimova |
| collection | DOAJ |
| description | Objective: to study the characteristics of manifestations of hormonal abnormalities in women with juvenile myoclonic epilepsy (JME) and to comparatively analyze identified syndromes.Patients and methods. Hormonal disorders were analyzed in 48 reproductive-aged women with JME, who had received antiepileptic drug (AED) mono- and bitherapy during one or more years.Results. 66.7% of the patients were found to have ovarian hormonal dysfunction manifesting itself as the development of polycystic ovary syndrome, hypogonadism, isolated hyperandrogenism, and hypoprogesteronemia. Clinically detected syndromes frequently appeared as menstrual irregularity in 29% of the patients. Comparative analysis of hormone-dependent syndromes showed that there were no differences in the clinical features of JME, but the earliest age at onset in isolated hyperandrogenism, and no patients with menstrual irregularity in the presence of isolated hypoprogesteronemia. The use of different AEDs had no impact on the incidence of hormonal abnormalities, which requires further investigation and its inclusion of a greater number of patients receiving various AEDs. |
| first_indexed | 2024-04-10T02:02:46Z |
| format | Article |
| id | doaj.art-29f2b6ebaa0242fd9df7bbff98691042 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:02:46Z |
| publishDate | 2017-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-29f2b6ebaa0242fd9df7bbff986910422023-03-13T08:42:16ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422017-06-0191S323810.14412/2074-2711-2017-1S-32-38638Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsyD. V. Anisimova0R. V. Magzhanov1P. N. Vlasov2V. A. Petrukhin3E. B. Tsevtsivadze4S. R. Nurmukhametova5Bashkir State Medical University, Ministry of Health of RussiaBashkir State Medical University, Ministry of Health of RussiaA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaMoscow Regional Research Institute of Obstetrics and GynecologyMoscow Regional Research Institute of Obstetrics and GynecologyBashkir State Medical University, Ministry of Health of RussiaObjective: to study the characteristics of manifestations of hormonal abnormalities in women with juvenile myoclonic epilepsy (JME) and to comparatively analyze identified syndromes.Patients and methods. Hormonal disorders were analyzed in 48 reproductive-aged women with JME, who had received antiepileptic drug (AED) mono- and bitherapy during one or more years.Results. 66.7% of the patients were found to have ovarian hormonal dysfunction manifesting itself as the development of polycystic ovary syndrome, hypogonadism, isolated hyperandrogenism, and hypoprogesteronemia. Clinically detected syndromes frequently appeared as menstrual irregularity in 29% of the patients. Comparative analysis of hormone-dependent syndromes showed that there were no differences in the clinical features of JME, but the earliest age at onset in isolated hyperandrogenism, and no patients with menstrual irregularity in the presence of isolated hypoprogesteronemia. The use of different AEDs had no impact on the incidence of hormonal abnormalities, which requires further investigation and its inclusion of a greater number of patients receiving various AEDs.https://nnp.ima-press.net/nnp/article/view/724juvenile myoclonic epilepsyantiepileptic therapyfollicle-stimulating hormoneluteinizing hormoneestradioltestosteroneprogesteronepolycystic ovary syndromehyperandrogenism, hypoprogesteronemiahypogonadism |
| spellingShingle | D. V. Anisimova R. V. Magzhanov P. N. Vlasov V. A. Petrukhin E. B. Tsevtsivadze S. R. Nurmukhametova Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy Неврология, нейропсихиатрия, психосоматика juvenile myoclonic epilepsy antiepileptic therapy follicle-stimulating hormone luteinizing hormone estradiol testosterone progesterone polycystic ovary syndrome hyperandrogenism, hypoprogesteronemia hypogonadism |
| title | Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy |
| title_full | Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy |
| title_fullStr | Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy |
| title_full_unstemmed | Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy |
| title_short | Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy |
| title_sort | analysis of hormone dependent pathology in female patients with juvenile myoclonic epilepsy |
| topic | juvenile myoclonic epilepsy antiepileptic therapy follicle-stimulating hormone luteinizing hormone estradiol testosterone progesterone polycystic ovary syndrome hyperandrogenism, hypoprogesteronemia hypogonadism |
| url | https://nnp.ima-press.net/nnp/article/view/724 |
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