Neural manifold under plasticity in a goal driven learning behaviour.
Neural activity is often low dimensional and dominated by only a few prominent neural covariation patterns. It has been hypothesised that these covariation patterns could form the building blocks used for fast and flexible motor control. Supporting this idea, recent experiments have shown that monke...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-02-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1008621 |
| _version_ | 1819008104949350400 |
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| author | Barbara Feulner Claudia Clopath |
| author_facet | Barbara Feulner Claudia Clopath |
| author_sort | Barbara Feulner |
| collection | DOAJ |
| description | Neural activity is often low dimensional and dominated by only a few prominent neural covariation patterns. It has been hypothesised that these covariation patterns could form the building blocks used for fast and flexible motor control. Supporting this idea, recent experiments have shown that monkeys can learn to adapt their neural activity in motor cortex on a timescale of minutes, given that the change lies within the original low-dimensional subspace, also called neural manifold. However, the neural mechanism underlying this within-manifold adaptation remains unknown. Here, we show in a computational model that modification of recurrent weights, driven by a learned feedback signal, can account for the observed behavioural difference between within- and outside-manifold learning. Our findings give a new perspective, showing that recurrent weight changes do not necessarily lead to change in the neural manifold. On the contrary, successful learning is naturally constrained to a common subspace. |
| first_indexed | 2024-12-21T00:35:11Z |
| format | Article |
| id | doaj.art-29f2fbf77d524cb29256c5ebba2fd054 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-21T00:35:11Z |
| publishDate | 2021-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-29f2fbf77d524cb29256c5ebba2fd0542022-12-21T19:21:49ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-02-01172e100862110.1371/journal.pcbi.1008621Neural manifold under plasticity in a goal driven learning behaviour.Barbara FeulnerClaudia ClopathNeural activity is often low dimensional and dominated by only a few prominent neural covariation patterns. It has been hypothesised that these covariation patterns could form the building blocks used for fast and flexible motor control. Supporting this idea, recent experiments have shown that monkeys can learn to adapt their neural activity in motor cortex on a timescale of minutes, given that the change lies within the original low-dimensional subspace, also called neural manifold. However, the neural mechanism underlying this within-manifold adaptation remains unknown. Here, we show in a computational model that modification of recurrent weights, driven by a learned feedback signal, can account for the observed behavioural difference between within- and outside-manifold learning. Our findings give a new perspective, showing that recurrent weight changes do not necessarily lead to change in the neural manifold. On the contrary, successful learning is naturally constrained to a common subspace.https://doi.org/10.1371/journal.pcbi.1008621 |
| spellingShingle | Barbara Feulner Claudia Clopath Neural manifold under plasticity in a goal driven learning behaviour. PLoS Computational Biology |
| title | Neural manifold under plasticity in a goal driven learning behaviour. |
| title_full | Neural manifold under plasticity in a goal driven learning behaviour. |
| title_fullStr | Neural manifold under plasticity in a goal driven learning behaviour. |
| title_full_unstemmed | Neural manifold under plasticity in a goal driven learning behaviour. |
| title_short | Neural manifold under plasticity in a goal driven learning behaviour. |
| title_sort | neural manifold under plasticity in a goal driven learning behaviour |
| url | https://doi.org/10.1371/journal.pcbi.1008621 |
| work_keys_str_mv | AT barbarafeulner neuralmanifoldunderplasticityinagoaldrivenlearningbehaviour AT claudiaclopath neuralmanifoldunderplasticityinagoaldrivenlearningbehaviour |