Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach
Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to incr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1504 |
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| author | Heshu Chen Chenyu Wang Zemin Liu Xinmiao He Wenjie Tang Liuqin He Yanzhong Feng Di Liu Yulong Yin Tiejun Li |
| author_facet | Heshu Chen Chenyu Wang Zemin Liu Xinmiao He Wenjie Tang Liuqin He Yanzhong Feng Di Liu Yulong Yin Tiejun Li |
| author_sort | Heshu Chen |
| collection | DOAJ |
| description | Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to increased intracellular lipid reactive oxygen species (ROS) accumulation and iron overload. Recent reports have shown that ferroptosis at the cellular and organism levels can prevent an inflammatory storm and cancer development. Emerging evidence suggests potential mechanisms (e.g., system Xc-, glutathione peroxidase 4 (GPX4), lipid peroxidation, glutathione (GSH), and iron chelators) are involved in ferroptosis, which may mediate biological processes such as oxidative stress and iron overload to treat cancer. To date, there are at least three pathways that mediate ferroptosis in cancer cells: system Xc-/GSH/GPX4, FSP1/CoQ10/NAD(P)H, and ATG5/ATG7/NCOA4. Here, we summarize recent advances in the occurrence and development of ferroptosis in the context of cancer, the associations between ferroptosis and various modulators, and the potential mechanisms and therapeutic strategies targeting ferroptosis for the treatment of cancer. |
| first_indexed | 2024-03-09T04:45:41Z |
| format | Article |
| id | doaj.art-29f555aeeecb4e578131b541f0a6cdfe |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:45:41Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-29f555aeeecb4e578131b541f0a6cdfe2023-12-03T13:15:42ZengMDPI AGAntioxidants2076-39212022-07-01118150410.3390/antiox11081504Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic ApproachHeshu Chen0Chenyu Wang1Zemin Liu2Xinmiao He3Wenjie Tang4Liuqin He5Yanzhong Feng6Di Liu7Yulong Yin8Tiejun Li9Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, ChinaAnimal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu 610066, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, ChinaInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaFerroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to increased intracellular lipid reactive oxygen species (ROS) accumulation and iron overload. Recent reports have shown that ferroptosis at the cellular and organism levels can prevent an inflammatory storm and cancer development. Emerging evidence suggests potential mechanisms (e.g., system Xc-, glutathione peroxidase 4 (GPX4), lipid peroxidation, glutathione (GSH), and iron chelators) are involved in ferroptosis, which may mediate biological processes such as oxidative stress and iron overload to treat cancer. To date, there are at least three pathways that mediate ferroptosis in cancer cells: system Xc-/GSH/GPX4, FSP1/CoQ10/NAD(P)H, and ATG5/ATG7/NCOA4. Here, we summarize recent advances in the occurrence and development of ferroptosis in the context of cancer, the associations between ferroptosis and various modulators, and the potential mechanisms and therapeutic strategies targeting ferroptosis for the treatment of cancer.https://www.mdpi.com/2076-3921/11/8/1504ferroptosislipid peroxidationironcanceroxidative stress |
| spellingShingle | Heshu Chen Chenyu Wang Zemin Liu Xinmiao He Wenjie Tang Liuqin He Yanzhong Feng Di Liu Yulong Yin Tiejun Li Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach Antioxidants ferroptosis lipid peroxidation iron cancer oxidative stress |
| title | Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach |
| title_full | Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach |
| title_fullStr | Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach |
| title_full_unstemmed | Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach |
| title_short | Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach |
| title_sort | ferroptosis and its multifaceted role in cancer mechanisms and therapeutic approach |
| topic | ferroptosis lipid peroxidation iron cancer oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/8/1504 |
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