Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses
PurposeBased on a large number of systematic reviews and meta-analyses exploring the relationship between psoriasis and various health outcomes, we conducted an comprehensive analysis to assess the strength and evidence for the association between psoriasis and medical end-point ramifications in pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.998815/full |
| _version_ | 1811282926762983424 |
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| author | Yun Zhou Yun Zhou Lixian Zhong Lianli Shen Sisi Chen Qiuting Zeng Leizhen Lai Shaohui Tang |
| author_facet | Yun Zhou Yun Zhou Lixian Zhong Lianli Shen Sisi Chen Qiuting Zeng Leizhen Lai Shaohui Tang |
| author_sort | Yun Zhou |
| collection | DOAJ |
| description | PurposeBased on a large number of systematic reviews and meta-analyses exploring the relationship between psoriasis and various health outcomes, we conducted an comprehensive analysis to assess the strength and evidence for the association between psoriasis and medical end-point ramifications in patients.MethodsWe searched related meta-analyses, investigating the links between psoriasis and medical ramifications from three databases. All summary effect sizes, 95% CIs, heterogeneity, and small-study effects in the included meta-analyses were recalculated. We assessed the methodological quality of included articles with the AMSTAR 2 tool and graded the epidemiological evidence. Subgroup analysis based on the severity of psoriasis and study design were also performed.ResultsA total of 38 articles comprising 85 unique meta-analyses were included in this study. Although 69 outcomes were statistically significant, only 8 outcomes (nonvascular dementia, ulcerative colitis, pediatric dyslipidemia, gestational diabetes, gestational hypertension, fracture, multiple sclerosis, and schizophrenia) showed a high quality of epidemiological evidence.ConclusionWe found that psoriasis increased the risk of 69 health outcomes, and 8 outcomes were graded as high-quality evidence. No evidence was found that psoriasis was beneficial for any medical end point. However, to verify our results, more large-sample, multi-center prospective cohort studies are needed. |
| first_indexed | 2024-04-13T02:01:22Z |
| format | Article |
| id | doaj.art-29f5ac884ea54284ab606c78094f67f3 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T02:01:22Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-29f5ac884ea54284ab606c78094f67f32022-12-22T03:07:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.998815998815Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analysesYun Zhou0Yun Zhou1Lixian Zhong2Lianli Shen3Sisi Chen4Qiuting Zeng5Leizhen Lai6Shaohui Tang7Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Gannan Medical University, Ganzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaPurposeBased on a large number of systematic reviews and meta-analyses exploring the relationship between psoriasis and various health outcomes, we conducted an comprehensive analysis to assess the strength and evidence for the association between psoriasis and medical end-point ramifications in patients.MethodsWe searched related meta-analyses, investigating the links between psoriasis and medical ramifications from three databases. All summary effect sizes, 95% CIs, heterogeneity, and small-study effects in the included meta-analyses were recalculated. We assessed the methodological quality of included articles with the AMSTAR 2 tool and graded the epidemiological evidence. Subgroup analysis based on the severity of psoriasis and study design were also performed.ResultsA total of 38 articles comprising 85 unique meta-analyses were included in this study. Although 69 outcomes were statistically significant, only 8 outcomes (nonvascular dementia, ulcerative colitis, pediatric dyslipidemia, gestational diabetes, gestational hypertension, fracture, multiple sclerosis, and schizophrenia) showed a high quality of epidemiological evidence.ConclusionWe found that psoriasis increased the risk of 69 health outcomes, and 8 outcomes were graded as high-quality evidence. No evidence was found that psoriasis was beneficial for any medical end point. However, to verify our results, more large-sample, multi-center prospective cohort studies are needed.https://www.frontiersin.org/articles/10.3389/fmed.2022.998815/fullpsoriasismedical ramificationsmeta-analysisepidemiological evidencequality |
| spellingShingle | Yun Zhou Yun Zhou Lixian Zhong Lianli Shen Sisi Chen Qiuting Zeng Leizhen Lai Shaohui Tang Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses Frontiers in Medicine psoriasis medical ramifications meta-analysis epidemiological evidence quality |
| title | Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses |
| title_full | Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses |
| title_fullStr | Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses |
| title_full_unstemmed | Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses |
| title_short | Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses |
| title_sort | psoriasis and medical ramifications a comprehensive analysis based on observational meta analyses |
| topic | psoriasis medical ramifications meta-analysis epidemiological evidence quality |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.998815/full |
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